Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조성신 | - |
dc.date.accessioned | 2021-04-08T05:54:25Z | - |
dc.date.available | 2021-04-08T05:54:25Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 10, no. 1, article no. 3097 | en_US |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.nature.com/articles/s41598-020-60047-w | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/161281 | - |
dc.description.abstract | Histological and cytological observations of the human anterior cruciate ligament (ACL) had been described, but the differentiation potency based on their location is still unknown. To determine and compare proliferation and differentiation potential of cells derived from distal and middle thirds of the ACL remnant, ACL remnant was initially marked at the distal third (within 10 mm from the tibial insertion) and middle third (between 10-20 mm from the tibial insertion) and then dissected. Both the middle and distal third regions of ACL remnant were analyzed using CD34(+) cell counting. Cell proliferation rate did not differ in both middle and distal third regions of ACL remnant, but they showed different characteristics in cell differentiation depending on their location. The distal third region of the ACL remnant had a tendency for chondrogenic differentiation with higher expression of CD34(+) cells. On the other hand, the middle third region of ACL remnant had a strong tendency for osteogenic and ligamentous differentiation. Characteristics of the ACL remnant tissues should be considered when performing remnant-preserving or harvesting ACL remnants for tissue engineering. | en_US |
dc.description.sponsorship | This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future (NRF-2016R1A2B4008606 and 2019R1A2C2004214 to T.K.) and the Ministry of Education (2017R1C1B5075203 to J.K.L. and 2017R1A6A3A11034394 to S.J.). The study was also supported by a Korea Health Technology R&D grant through the Korea Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health & Welfare, Republic of Korea (HI17C0888 to T.K.). | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | ENDOTHELIAL PROGENITOR CELLS | en_US |
dc.subject | MESENCHYMAL STEM-CELLS | en_US |
dc.subject | TENSIONING TECHNIQUE | en_US |
dc.subject | GROWTH-FACTOR | en_US |
dc.subject | RECONSTRUCTION | en_US |
dc.subject | GRAFT | en_US |
dc.subject | 2ND-LOOK | en_US |
dc.subject | RABBIT | en_US |
dc.subject | TRANSPLANTATION | en_US |
dc.subject | SYNOVIALIZATION | en_US |
dc.title | Anterior cruciate ligament remnant cells have different potentials for cell differentiation based on their location | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41598-020-60047-w | - |
dc.relation.page | 1-9 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Lee, Jin Kyu | - |
dc.contributor.googleauthor | Jo, Sungsin | - |
dc.contributor.googleauthor | Lee, Young Lim | - |
dc.contributor.googleauthor | Park, Hyosun | - |
dc.contributor.googleauthor | Song, Jun-Seob | - |
dc.contributor.googleauthor | Sung, Il-Hoon | - |
dc.contributor.googleauthor | Kim, Tae-Hwan | - |
dc.relation.code | 2020051242 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | RHEUMATISM CENTER | - |
dc.identifier.pid | joejo0517 | - |
dc.identifier.orcid | http://orcid.org/0000-0003-3034-5029 | - |
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