Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 신승훈 | - |
dc.contributor.author | 신상익 | - |
dc.date.accessioned | 2021-02-24T16:05:17Z | - |
dc.date.available | 2021-02-24T16:05:17Z | - |
dc.date.issued | 2021. 2 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/159017 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000485807 | en_US |
dc.description.abstract | Ynamides have recently emerged as key building blocks in organic synthesis, The electron-donating ability of the nitrogen atom strongly polarizes the triple bond, allowing for transformations to proceed with levels of chemo-, regio-, and stereo-selectivities that cannot be reached with classical alkynes. Ynamides are therefore extremely versatile reagents. Recently, it was found that mCPBA oxidize ynamides at the unconventional β-position, leading to N,O-acetals. We studied the reactions of the N,O-acetals and found that they underwent transacetalization with benzotriazoles, leading to N,N-acetals in the presence of Zn(OTf)2 catalyst. We also found that use of Hexafluoroisopropanol significantly accelerated the reaction, improved the N1/N2 regioisomeric ratio. The transacetalization conditions developed could be extended to other N-donors, such as 1H-indazole and TMSN3 to afford the corresponding N,N-acetals. | - |
dc.publisher | 한양대학교 | - |
dc.title | Zinc-Catalyzed Transacetalization of N,O-Acetals into N,N-Acetals with Benzotriazoles, Indazoles, and Azides | - |
dc.type | Theses | - |
dc.contributor.googleauthor | Sang Ik Shin | - |
dc.contributor.alternativeauthor | 신상익 | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 화학과 | - |
dc.description.degree | Master | - |
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