Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이철훈 | - |
dc.date.accessioned | 2021-01-20T01:14:03Z | - |
dc.date.available | 2021-01-20T01:14:03Z | - |
dc.date.issued | 2002-04 | - |
dc.identifier.citation | Journal of Microbiology and Biotechnology, v. 12, no. 2, page. 222-227 | en_US |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.issn | 1738-8872 | - |
dc.identifier.uri | http://kiss.kstudy.com/thesis/thesis-view.asp?key=2752408 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/157175 | - |
dc.description.abstract | Squalene synthase catalyzes the reductive dimerization of two molecules of farnesyl diphosphate to form squalene at the final branch point of the cholesterol biosynthetic pathway. Due to the unique position of this enzyme in the pathway, its inhibitors may have advantages as antihypercholesterolemic agents. Therefore, selective inhibitors of squalene synthase do not prevent the formation of the essential branch products of the isoprene pathway, such as dolichol, coenzyme-Q, and prenylated proteins, as might be expected for inhibitors of enzymes earlier in the pathway; for example, lovastatin and mevalotin. The current study reports that CJ90002, a pentagalloylglucose isolated from Paeonia moutan SIM (Paeoniaceae), which is an important Chinese crude drug used in many traditional prescriptions, was a potent inhibitor of rat microsomal squalene synthase, and also a potent inhibitor of cholesterol biosynthesis in vitro. In addition, the intraperitoneal and oral administration of CJ90002 had a significant lowering effect on plasma cholesterol levels in hamsters. | en_US |
dc.description.sponsorship | This work was supported by a research fund of Hanyang University (HY-2000-75). All NMR measurements using a Bruker Advance 400 spectrometer system were partially supported by the Shared Research Equipment Assistance Program (R23-2001-00002) of the Korea Basic Science Institute. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | 한국미생물생명공학회 | en_US |
dc.subject | Cholesterol Lowering agent | en_US |
dc.subject | squalene synthase | en_US |
dc.subject | Paeonia moutan | en_US |
dc.subject | pentagalloylglucose | en_US |
dc.title | Hypocholestrolemic effect of CJ90002 in hamsters: A potent inhibitor for squalene synthase from Paeonia moutan | en_US |
dc.type | Article | en_US |
dc.relation.journal | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.contributor.googleauthor | Park, Jong Koo | - |
dc.contributor.googleauthor | Cho, Hi Jae | - |
dc.contributor.googleauthor | Lim, Yoon Gho | - |
dc.contributor.googleauthor | Cho, Youl Hee | - |
dc.contributor.googleauthor | Lee, Chul Hoon | - |
dc.relation.code | 2008205425 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | chhlee | - |
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