Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황승용 | - |
dc.date.accessioned | 2020-12-10T03:47:08Z | - |
dc.date.available | 2020-12-10T03:47:08Z | - |
dc.date.issued | 2003-07 | - |
dc.identifier.citation | Molecular and cellular biology v. 23, no. 10, page. 3583-3592 | en_US |
dc.identifier.issn | 3583–3592 | - |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC164762/?tool=pubmed | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/156101 | - |
dc.description.abstract | Activating signal cointegrator 2 (ASC-2), a cancer-amplified transcriptional coactivator of nuclear receptors and many other transcription factors, contains two LXXLL-type nuclear receptor interaction domains. Interestingly, the second LXXLL motif is highly specific to the liver X receptors (LXRs). In cotransfection, DN2, an ASC-2 fragment encompassing this motif, exerts a potent dominant-negative effect on transactivation by LXRs, which is rescued by ectopic coexpression of the full-length ASC-2 but not by other LXXLL-type coactivators, such as SRC-1 and TRAP220. In contrast, DN2/m, in which the LXXLL motif is mutated to LXXAA to abolish the interactions with LXRs, is without any effect. Accordingly, expression of DN2, but not DN2/m, in transgenic mice results in phenotypes that are highly homologous to those previously observed with LXRα−/− mice, including a rapid accumulation of large amounts of cholesterol and down-regulation of the known lipid-metabolizing target genes of LXRα in the liver upon being fed a high-cholesterol diet. These results identify ASC-2 as a physiologically important transcriptional coactivator of LXRs and demonstrate its pivotal role in the liver lipid metabolism. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | AMER SOC MICROBIOLOGY | en_US |
dc.title | Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1128/MCB.23.10.3583-3592.2003 | - |
dc.relation.journal | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.contributor.googleauthor | Kim, Seung-Whan | - |
dc.contributor.googleauthor | Park, Keunhee | - |
dc.contributor.googleauthor | Kwak, Eunyee | - |
dc.contributor.googleauthor | Choi, Eunho | - |
dc.contributor.googleauthor | Lee, Seunghee | - |
dc.contributor.googleauthor | Ham, Jungyeob | - |
dc.contributor.googleauthor | Kang, Heonjoong | - |
dc.contributor.googleauthor | Kim, Jong Man | - |
dc.contributor.googleauthor | Hwang, Seung Yong | - |
dc.contributor.googleauthor | Kong, Young-Yun | - |
dc.contributor.googleauthor | Lee, Keesook | - |
dc.contributor.googleauthor | Lee, Jae Woon | - |
dc.relation.code | 2007206798 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF MOLECULAR AND LIFE SCIENCE | - |
dc.identifier.pid | syhwang | - |
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