Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임형신 | - |
dc.date.accessioned | 2020-11-26T01:26:56Z | - |
dc.date.available | 2020-11-26T01:26:56Z | - |
dc.date.issued | 2003-06 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v. 305, issue. 4, page. 974-980 | en_US |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0006291X03008702?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/155933 | - |
dc.description.abstract | In this study we show that panaxadiol, a ginseng saponin with a dammarane skeleton, induces apoptotic cell death by depolarization of mitochondrial membrane potential in human hepatoma SK-HEP-1 cells. Sequential activation of caspases-9, -3, and -7, but not of caspase-8, occurs after mitochondrial membrane depolarization and cytochrome c release from the mitochondria of panaxadiol-treated cells. Moreover, Cdk2 kinase activity, but not Cdc2 kinase activity, is markedly upregulated in the early stages of apoptosis. Olomoucine or roscovitine, specific Cdks inhibitors, effectively prevent mitochondrial membrane depolarization as well as apoptotic cell death in panaxadiol-treated cells. Thus, panaxadiol-treatment induces cell death-dependent activation of Cdk2 kinase activity, which is functionally associated with depolarization of mitochondrial membrane potential and subsequent cytochrome c release. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Caspase cascade | en_US |
dc.subject | Cdk2 | en_US |
dc.subject | Cytochrome c release | en_US |
dc.subject | Mitochondrial membrane depolarization | en_US |
dc.title | Cdk2 activity is associated with depolarization of mitochondrial membrane potential during apoptosis | en_US |
dc.type | Article | en_US |
dc.relation.volume | 305 | - |
dc.identifier.doi | 10.1016/S0006-291X(03)00870-2 | - |
dc.relation.page | 974-980 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.contributor.googleauthor | Jin, Ying Hua | - |
dc.contributor.googleauthor | Yim, Hyungshin | - |
dc.contributor.googleauthor | Park, Jeong Hill | - |
dc.contributor.googleauthor | Lee, Seung Ki | - |
dc.relation.code | 2008201235 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hsyim | - |
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