Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배옥남 | - |
dc.date.accessioned | 2020-11-10T01:32:43Z | - |
dc.date.available | 2020-11-10T01:32:43Z | - |
dc.date.issued | 2003-03 | - |
dc.identifier.citation | 한국독성학회지, v. 19, no. 1, page. 33-37 | en_US |
dc.identifier.issn | 1976-8257 | - |
dc.identifier.uri | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART000918700 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/155290 | - |
dc.description.abstract | Asiaticoside has been tested for the ability as an anti-inflammatory drug using lipopolysaccharide (LPS)-stimulated macrophage cell line (RAW 264.7 cell). LPS treatment induced dramatically inducible nitric oxide synthase (iNOS) in RAW cells. However, asiaticoside inhibited LPSstimulated iNOS induction in a concentration-dependent manner. Especially, higher concentrations (> 50 mM) of asiaticoside completely blocked iNOS induction. In addition, LPS-stimulated expression of inducible cyclooxygenase (COX-2) and interleukin-1a (IL-1a) was inhibited by asiaticoside treatment. Asiaticoside up to 50 mM still required to inhibit COX-2 and IL-1a induced by LPS. Consistent with these findings, treatment with asiaticoside suppressed de novo synthesis and cellular accumulation of prostaglandin E2 to a lesser extent, suggesting that asiaticoside blocked the induction as well as the activity of COX-2. These results suggest the possibility that asiaticoside may be effective therapeutic agents for septic shock and other inflammatory diseases. | en_US |
dc.language.iso | ko_KR | en_US |
dc.publisher | 한국독성학회 | en_US |
dc.subject | Asiaticoside | en_US |
dc.subject | Inducible nitric oxide synthase | en_US |
dc.subject | Cyclooxygenase-2 | en_US |
dc.subject | Lipopolysaccharide | en_US |
dc.subject | Anti-inflammatory activities. | en_US |
dc.title | Asiaticoside가 RAW 264.7 세포에서 Inducible nitric oxide synthase 와 Cyclooxygenase-2에 미치는 향염증 작용에 관한 연구 | en_US |
dc.title.alternative | Anti-inflammatory Effects of Asiaticoside on Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in RAW 264.7 Cell Line | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 19 | - |
dc.relation.page | 33-37 | - |
dc.relation.journal | 한국독성학회지 | - |
dc.contributor.googleauthor | 주상섭 | - |
dc.contributor.googleauthor | 배옥남 | - |
dc.contributor.googleauthor | 정진호 | - |
dc.relation.code | 2012210963 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | onbae | - |
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