Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정일엽 | - |
dc.date.accessioned | 2020-10-26T02:20:29Z | - |
dc.date.available | 2020-10-26T02:20:29Z | - |
dc.date.issued | 2004-12 | - |
dc.identifier.citation | In Cellular Immunology, v.232, Issue.1-2, Page.57-63 | en_US |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0008874905000225 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/154807 | - |
dc.description.abstract | Since we have previously shown that dexamethasone (Dex) enhances the proportion of murine Treg cells, we tested the effect of IL-7, a promoter of T cell survival, together with Dex oil human CD4(+)CD25(+) Treg cells in an in vitro setting. The results showed that IL-7 in concert with Dex markedly augmented the generation of CD4(+)CD25(+) T cells. To discern the origin of the induced CD4(+)CD25(+) T cells, MACS-purified CD4(+)CD25(-), and CD4(+)CD25(+) cells were cultured in the presence of Dex and/or IL-7 for 4 days. Although two thirds of CD4(+)CD25(-) T cells became CD4(+)CD25(+) T cells, they had no Suppressive activity. In contrast, the original CD4(+)CD25(+) T cells maintained Suppressive activity after Dex/IL-7 treatment, however, there was not a significant expansion ill their cell number. Dex and IL-7 did not induce additional Treg cells, but additively induced the expression of the activation marker CD25 by CD4(+)CD25(-) T cells. This combination may provide a novel means of priming CD4 T cells to respond to IL-2 and may prove useful in up-regulation of normal immune responses in immune deficient diseases. (c) 2005 Elsevier Inc. All rights reserved. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier Inc. | en_US |
dc.subject | CD4+CD25+ regulatory T lymphocyte | en_US |
dc.subject | Dexamethasone | en_US |
dc.subject | Interleukin-7 | en_US |
dc.subject | Suppression/anergy | en_US |
dc.title | Effects of IL-7 and dexamethasone: Induction of CD25, the high affinity IL-2 receptors, on human CD4+ cells. | en_US |
dc.type | Article | en_US |
dc.relation.journal | CELLULAR IMMUNOLOGY | - |
dc.contributor.googleauthor | Chung, Il Yup | - |
dc.contributor.googleauthor | Dong, Hui Fang | - |
dc.contributor.googleauthor | Zhang, Xia | - |
dc.contributor.googleauthor | Hassanein, Nahed M.A. | - |
dc.contributor.googleauthor | Howard, O.M. Zack | - |
dc.contributor.googleauthor | Chen, Xin | - |
dc.relation.code | 2009201752 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF MOLECULAR AND LIFE SCIENCE | - |
dc.identifier.pid | iychu | - |
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