Laser-generated focused ultrasound transmitters with frequency-tuned outputs over sub-10-MHz range

Abstract

Previous laser-generated focused ultrasound (LGFU) systems have been operated with ˃15 MHz frequency, allowing for high spatial precision (mu m). However, they have been limited only to proximal biomedical applications ex vivo with treatment depths smaller than 10 mm from the lens surface. Although the low-megahertz frequency operation has the advantage of a longer range of therapy, this requires a proper photoacoustic lens made of a nanocomposite coating over a spherically curved substrate whose transmission layer is physically designed for frequency-tuned outputs. This demands a fabrication method that can provide such a nanocomposite structure. We demonstrate photoacoustic lenses operated in an unexplored frequency range of 1-10 MHz, which can simultaneously produce high-amplitude pressure outputs sufficient for pulsed acoustic cavitation. We physically design a spatially elongated photoacoustic output and then fabricate a transmitter by controlling the density of light-absorbing nanoscale elements in a solution form and by using a replica mold to shape the lens curvature. Our approach is validated by fabricating and characterizing planar transmitters and then applied to focal configurations. This offers various possibilities for LGFU-based treatments (e.g., pulsed cavitational therapy such as histotripsy) over the low-megahertz frequency range, which has not been realized by conventional LGFU systems.