Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김기현 | - |
dc.date.accessioned | 2020-10-06T08:09:09Z | - |
dc.date.available | 2020-10-06T08:09:09Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | Journal of Cleaner Production, v. 234, Page. 329-339 | en_US |
dc.identifier.issn | 0959-6526 | - |
dc.identifier.issn | 1879-1786 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0959652619320359?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/154408 | - |
dc.description.abstract | Various forms of α-amino nitrile molecules are found to exert strong impacts on the synthesis of multiple organic compounds such as pharmaceuticals, amino acids, agrochemical agents, and pesticides. Spherical ZnO nanoparticles (NPs) prepared by a simple co-precipitation method are an efficient heterogeneous catalyst for the synthesis of vital intermediate α-amino nitriles. The present protocol was investigated via one-pot synthesis of α-amino nitriles over ZnO NPs using a three-component coupling reaction of aldehydes, amines, and trimethylsilyl cyanide in acetonitrile. The feasibility of our synthesis approach was assessed with respect to the purity and yield of synthesized products in relation to several controlling variables (e.g., ZnO molar ratio, reaction time, amines/aldehydes types, and solvent). The qualitative characteristics of α-amino nitrile products were evaluated by Fourier transform infrared (FTIR) spectroscopy, nuclear magnetic resonance (NMR), and mass spectroscopic analysis. A high yield (81–95%) of pure α-amino nitriles within a short reaction time (45–75 min) along with good recyclability of the catalyst (e.g., without significant loss in performance over five cycles) was confirmed as the distinctive merits of this new eco-friendly synthetic method. This study confirms that various amines including sterically crowded secondary amines should react efficiently with benzenoid plus non-benzenoid aldehyde to yield α-amino nitriles. The selected route is very fast as well as economical. Hence, this method can be used for large-scale production of a variety of biologically important molecules through α-amino nitriles. | en_US |
dc.description.sponsorship | The authors are thankful to the Sophisticated Instrument Centre, Punjabi University, Patiala and Lajpat Rai D.A.V. College Jagraon for providing the necessary facilities. One of the author Balwinder Kaur is highly obliged to UGC for providing a MANF fellowship. The authors are grateful to SAIF, Panjab University, Chandigarh for TEM, IR, & NMR analyses. KHK acknowledges the support of the R&D Centre for Green Patrol Technologies through the R&D for Global Top Environmental Technologies funded by the Ministry of Environment (Grant No: 2018001850001) as well as a grant from the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future Planning (Grant No: 2016R1E1A1A01940995). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier BV | en_US |
dc.subject | ZnO | en_US |
dc.subject | Heterogeneous catalysis | en_US |
dc.subject | Recyclability | en_US |
dc.subject | Organic synthesis | en_US |
dc.subject | Strecker reaction | en_US |
dc.subject | alpha-amino nitriles | en_US |
dc.subject | Acetonitrile | en_US |
dc.title | One-pot three-component synthesis of α-amino nitriles using ZnO as a heterogeneous, reusable, and eco-friendly catalyst | en_US |
dc.type | Article | en_US |
dc.relation.volume | 234 | - |
dc.identifier.doi | 10.1016/j.jclepro.2019.06.080 | - |
dc.relation.page | 329-339 | - |
dc.relation.journal | Journal of Cleaner Production | - |
dc.contributor.googleauthor | Kaur, Balwinder | - |
dc.contributor.googleauthor | Chand, Subhash | - |
dc.contributor.googleauthor | Malik, Ashok Kumar | - |
dc.contributor.googleauthor | Dhaliwal, Karamjit Singh | - |
dc.contributor.googleauthor | Younis, Sherif A. | - |
dc.contributor.googleauthor | Kim, Ki-Hyun | - |
dc.relation.code | 2019021489 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF CIVIL AND ENVIRONMENTAL ENGINEERING | - |
dc.identifier.pid | kkim61 | - |
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