Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영창 | - |
dc.date.accessioned | 2020-09-10T07:29:48Z | - |
dc.date.available | 2020-09-10T07:29:48Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | CELLS, v. 8, no. 10, article no. 1180 | en_US |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://www.mdpi.com/2073-4409/8/10/1180 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/153745 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of complex etiology that primarily affects women of childbearing age. The development of SLE is attributed to the breach of immunological tolerance and the interaction between SLE-susceptibility genes and various environmental factors, resulting in the production of pathogenic autoantibodies. Working in concert with the innate and adaptive arms of the immune system, lupus-related autoantibodies mediate immune-complex deposition in various tissues and organs, leading to acute and chronic inflammation and consequent end-organ damage. Over the past two decades or so, the impact of genetic susceptibility on the development of SLE has been well demonstrated in a number of large-scale genetic association studies which have uncovered a large fraction of genetic heritability of SLE by recognizing about a hundred SLE-susceptibility loci. Integration of genetic variant data with various omics data such as transcriptomic and epigenomic data potentially provides a unique opportunity to further understand the roles of SLE risk variants in regulating the molecular phenotypes by various disease-relevant cell types and in shaping the immune systems with high inter-individual variances in disease susceptibility. In this review, the catalogue of SLE susceptibility loci will be updated, and biological signatures implicated by the SLE-risk variants will be critically discussed. It is optimistically hoped that identification of SLE risk variants will enable the prognostic and therapeutic biomarker armamentarium of SLE to be strengthened, a major leap towards precision medicine in the management of the condition. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.subject | genetics | en_US |
dc.subject | epigenetics | en_US |
dc.subject | genome | en_US |
dc.subject | lupus | en_US |
dc.subject | SLE | en_US |
dc.title | Update on the Genetics of Systemic Lupus Erythematosus: Genome-Wide Association Studies and Beyond | en_US |
dc.type | Article | en_US |
dc.relation.no | 1180 | - |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.3390/cells8101180 | - |
dc.relation.page | 1-17 | - |
dc.relation.journal | CELLS | - |
dc.contributor.googleauthor | Kwon, Young-Chang | - |
dc.contributor.googleauthor | Chun, Sehwan | - |
dc.contributor.googleauthor | Kim, Kwangwoo | - |
dc.contributor.googleauthor | Mak, Anselm | - |
dc.relation.code | 2019041490 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | RHEUMATISM CENTER | - |
dc.identifier.pid | yckwon83 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.