Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김철근 | - |
dc.contributor.author | 이연주 | - |
dc.date.accessioned | 2020-08-28T16:52:11Z | - |
dc.date.available | 2020-08-28T16:52:11Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/153045 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000438205 | en_US |
dc.description.abstract | The transcription factor CP2c plays an important role as an oncogene and controls cell proliferation, cell cycle, and differentiation. We previously identified that a CP2c-targeting peptide derivative led to apoptotic cell death of cancer cell lines of various origins when it was linked to the cell-penetrating peptide iRGD, with no adverse effect on normal cells. We called this peptide derivative ACP52C (anti-cancer peptide 52C). Importantly, compared to most cancer cell lines, the non-small cell lung cancer (NSCLC) cell lines were resistant to the anticancer effect of ACP52C. In this study, I found that NSCLC cells, compared to other cancer cell types, express murine double minute 2 (MDM2) protein at low levels of its 90 kDa isoform (p90) and high levels of its 60 kDa isoform (p60). I confirmed that high levels of MDM2 p60 in NSCLC were caused by caspase 2-mediated protein cleavage but not by alternative splicing or the SNP mutantion, consistent with the previous reports. Conditional overexpression of MDM2 p90 or treatment with a caspase 2 inhibitor could overcome the resistance to ACP52C leading to the cell death. Therefore, these results suggest that ACP52C resistance in NSCLC is caused by a tilted balance between MDM2 p60 and p90 levels and could be overcome by inhibiting the caspase 2 activity. | - |
dc.publisher | 한양대학교 | - |
dc.title | Molecular mechanism of resistance to the anticancer drug ACP52C in the A549 cell line | - |
dc.type | Theses | - |
dc.contributor.googleauthor | Yeon Ju Lee | - |
dc.contributor.alternativeauthor | 이연주 | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 생명과학과 | - |
dc.description.degree | Master | - |
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