Diffusion Tensor Imaging Analysis of White Matter Microstructural Integrity in Infants With Retinopathy of Prematurity
- Title
- Diffusion Tensor Imaging Analysis of White Matter Microstructural Integrity in Infants With Retinopathy of Prematurity
- Author
- 안성준
- Keywords
- diffusion tensor imaging; magnetic resonance imaging; retinopathy of prematurity; white matter
- Issue Date
- 2019-07
- Publisher
- ASSOC RESEARCH VISION OPHTHALMOLOGY INC
- Citation
- INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 60, no. 8, Page. 3024-3033
- Abstract
- PURPOSE. To investigate white matter maturation in preterm infants with and without retinopathy of prematurity (ROP) and to determine whether ROP is associated with white matter microstructural integrity at term-equivalent ages.
METHODS. In 82 preterm and 34 full-term infants who had undergone brain magnetic resonance imaging diffusion tensor imaging at term-equivalent ages, white matter microstructural integrity was assessed based on mean fractional anisotropy (FA) and mean diffusivity (MD) values in 23 predefined regions of interest by using atlas-based analyses. The values were compared among preterm and full-term infants, and a general linear model was used to evaluate the association of the values with ROP or severe (i.e., stage >= 3) ROP.
RESULTS. Significant differences in FA and MD values were observed among preterm and full-term infants in 17 (73.9%) and 15 (65.2%) of the 23 white matter areas evaluated, respectively. However, ROP was significantly associated with MD values in only two areas (superior longitudinal fasciculus [P = 0.030] and cerebral peduncle [P = 0.005]). Severe ROP was significantly associated with FA values within the anterior limb of the internal capsule (P = 0.049) and MD values within the stria terminalis (P = 0.035). A network analysis showed that preterm infants with severe ROP had lower small-world index values than those without.
CONCLUSIONS. Preterm birth may be more strongly associated with white matter maturation at term-equivalent ages than ROP, but severe ROP may be associated with decreased structural connectivity.
- URI
- http://iovs.arvojournals.org/article.aspx?articleid=2738360https://repository.hanyang.ac.kr/handle/20.500.11754/152330
- ISSN
- 0146-0404; 1552-5783
- DOI
- 10.1167/iovs.18-25849
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML