Natural course of fatty liver in 36,195 South Korean adults
- Title
- Natural course of fatty liver in 36,195 South Korean adults
- Author
- 신정훈
- Keywords
- INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS; DISEASE
- Issue Date
- 2019-07
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v. 9, article no. 9062
- Abstract
- Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease, and yet the natural course remains unclear. Study population included 36,195 individuals who participated in a health-screening program and diagnosed with fatty liver by abdominal ultrasound. Participants were provided written information regarding fatty liver and advised to make lifestyle changes. Ultrasound was repeated after at least 6 months. After a mean follow up of 4.9 years (+/- 3.4), 19.6% resolved their fatty liver. Individuals who resolved were more likely female (22.9% vs. 12.3%), thinner (body mass index [BMI], 25.2 +/- 2.7 vs. 26 +/- 2.7), and with lower HOMA-IR (1.4 vs. 1.7) (P.70.001). Decrease in BMI predicted resolution of fatty liver with 42% of those in the top quartile of BMI decline resolving compared with 5.7% in the lowest quartile (odds ratio [OR] (95% confidence interval [CI]) 15.65 (14.13-17.34), P ˂ 0.001)). Baseline HOMA-IR also predicted resolution with those in the top quartile (most insulin resistant) being least likely to resolve (12%) vs. those in the lowest quartile (25%) (OR 0.36 [0.31-0.42], P ˂ 0.001). Fatty liver disease is persistent. Individuals with higher degree of insulin resistance are also the most likely to have persistent steatosis at follow up.
- URI
- https://www.nature.com/articles/s41598-019-44738-7https://repository.hanyang.ac.kr/handle/20.500.11754/152177
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-019-44738-7
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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