Gold-Catalyzed Synthesis of 4-Substituted-oxazolidin-2-ones from N-Boc propargyl Amines

Abstract

Au(I)-complex catalyze cyclization of N-Boc propargyl amines into 4-alkyl oxazolidin-2-ones. This catalytic procedure provides access to a variety of 4-substituted oxazolidinones that are important in asymmetric synthesis and medicinal chemistry. The reaction is characterized by the low catalyst loading, mild reaction condition and operational simplicity.