Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이상경 | - |
dc.contributor.author | 박민선 | - |
dc.date.accessioned | 2020-04-01T17:04:25Z | - |
dc.date.available | 2020-04-01T17:04:25Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/142652 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000413065 | en_US |
dc.description.abstract | Arginine-grafted Bioreducible Polymer (ABP) could deliver significant amounts of DNA and siRNA into the cytoplasm. We made a melanoma cancer model by subcutaneously injecting murine melanoma cells (B16F10 cells) into C57BL/6 mice and then tested that ABP/siRNA effected on the various cell lines in vitro or in vivo systems. The B16F10 mouse model of melanoma shows that tumor angiogenesis is a critical process involved in solid tumor growth. Within 3~5days after tumor challenge, B16-F10 rapidly develops a network of tumor vasculature and up-regulates expression of the proangiogenic vascular endothelial growth factors. Upregulation of proangiogenic factors and downregulation of antiangiogenic factors define a molecular signature in growing tumors, called the angiogenic switch. Taking advantages of ABP holding genes, leading higher transfection effeciency and having lower cytotoxicity and designing a combinational siRNA silencing the genes related to antiapoptosis may become a potent candidate drug for cancer therapy. Here, we confirmed the possibilities of siRNA and ABP polyplex as antitumoral drugs through accomplishing melanoma studies basically using various siRNA silencing endogenous mRNA. | - |
dc.publisher | 한양대학교 | - |
dc.title | Cancer therapy with novel siRNA delivery bioreducible polymer | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 박민선 | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 생명공학과 | - |
dc.description.degree | Master | - |
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