간경변증 환자에서 간성뇌증에 대한 acetyl-L-carnitine 의 약리효과
- Title
- 간경변증 환자에서 간성뇌증에 대한 acetyl-L-carnitine 의 약리효과
- Other Titles
- Effects of acetyl-L-carnitine in cirrhotic patients with Hepatic encephalopathy
- Author
- 백수영
- Alternative Author(s)
- Back, su young
- Advisor(s)
- 이민호
- Issue Date
- 2010-02
- Publisher
- 한양대학교
- Degree
- Master
- Abstract
- AIM : To assess the clinical efficacy of acetyl-L-carnitine in the treatment of hepatic encephalopathy in cirrhotic patient, especially in diminishing the recurrence and reduction serum ammonia level.
Methods : We performed a randomized double-blind, placebo-
controlled, cross-over study. We administered acetyl-L-carnitine to group 1 during 3 months first then placebo during later 3 months, and administering acetyl-L-carnitine to group 2 alternatively.
Results : Between January 2008 and February 2008, thirty two selected cirrhotic patients were enrolled in this study. Following randomization, the patients were divided into two groups(group 1=14, group 2=18). During administering acetyl-L-carnitine period, serum ammonia level was decreased significantly in all groups(group 1; p=0.005, group 2; p=0.001). In group 1, the first recurrence cases of hepatic encephalopathy were more than group 2(group 1=5, group 2=2), and the first recurrences were occurred during first 3 months in all groups.
Conclusion : Our study demonstrates that acetyl-L-carnitine administration reducted serum ammonia level, but not definitely diminishing the recurrence of hepatic encephalopathy.
- URI
- https://repository.hanyang.ac.kr/handle/20.500.11754/142277http://hanyang.dcollection.net/common/orgView/200000413358
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > MEDICINE(의학과) > Theses (Master)
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML