Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 임태연 | - |
dc.contributor.author | 안수정 | - |
dc.date.accessioned | 2020-03-27T17:02:26Z | - |
dc.date.available | 2020-03-27T17:02:26Z | - |
dc.date.issued | 2010-08 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/141516 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000415593 | en_US |
dc.description.abstract | Platelet-rich plasma (PRP) is known to stimulate skin wound healing. In this study, we investigated whether long-term delivery of growth factors contained in PRP enhances skin regeneration as compared to short-term delivery. Heparin-conjugated poly(L-lactide-co-glycolide) nanospheres (HCPNs) were used as a vehicle for long-term delivery of growth factors contained in PRP. Fibrin gel, HCPN-loaded fibrin gel, PRP-loaded fibrin gel, and PRP-loaded HCPNs suspended in fibrin gel were implanted to full thickness skin defects of mice. The wound area was significantly reduced in group of PRP-loaded HCPNs suspended in fibrin gel compared to the other groups. Suprabasal cytokeratin differentiation in squamous neoepithelium was greatest in group of PRP-loaded HCPNs suspended in fibrin gel. This study demonstrates that a long-term delivery of growth factors contained in PRP enhances skin wound healing and neovascularization in neodermis. | - |
dc.publisher | 한양대학교 | - |
dc.title | 헤파린이 결합된 PLGA 나노입자와 혈소판이 풍부한 혈장을 이용한 피부재생 | - |
dc.title.alternative | Skin regeneration using platelet-rich plasma and heparin-conjugated PLGA nanospheres | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 안수정 | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 생명공학과 | - |
dc.description.degree | Master | - |
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