Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 류성언 | - |
dc.contributor.author | 전정이 | - |
dc.date.accessioned | 2020-03-26T16:59:43Z | - |
dc.date.available | 2020-03-26T16:59:43Z | - |
dc.date.issued | 2011-02 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/140011 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000416081 | en_US |
dc.description.abstract | Cdc25B, PTPs, and VHR, DSP(Dual-specificity phosphatases) families, have been considered as attractive drug targets for anti-cancer therapy. For Cdc25B phosphatase, we identified the inhibition effect of compounds which is obtained by structure-based virtual screening, through cytotoxicity test. And for MKP and VHR phosphatase, we tested that effect of compounds through enzyme activity test with fluorogenic substrate DiFMUP. As a results, we obtained three effective inhibitor of Cdc25B phosphatase, two to four inhibitor of each MKPs, and two inhibitor of VHR. These compounds will be used for making enzyme-inhibitor complex. And then it can be used as an anti-cancer drug, if it has an inhibition effect for animal model. | - |
dc.publisher | 한양대학교 | - |
dc.title | 구조에 기반한 virtual screening을 통해 발견한 dual phosphatase inhibitor의 활성분석 | - |
dc.title.alternative | Activity analysis of novel dual phosphatase inhibitors found from structure-based virtual screening | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 전정이 | - |
dc.contributor.alternativeauthor | Jeon, Jeong Yi | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 생명공학과 | - |
dc.description.degree | Master | - |
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