부분 탈모 환자에 있어서 PRP(Platelet Rich Plasma) 주사 치료의 임상적 유용성

Abstract

여러 가지 사회적, 환경적 요인들로 인해 탈모의 유병률은 점점 증가하고 있고, 그로 인해 탈모치료에 대한 수요는 점차 높아지고 있는 것이 현재의 추세이다. 그에 따라 다양한 탈모 치료법들이 등장하고 있지만, 탈모 자체가 진행성 질환이기 때문에 확실한 치료법이 제시되지 못하는 실정이다. 그에 따라 보다 비침습적이고 예방적인 치료법에 대한 수요가 대두되게 되었고 이러한 요구에 맞춰 등장한 치료법이 자가 PRP(platelet rich plasma) 주사치료라 할 수 있다. 기존의 연구결과를 바탕으로 PRP에 내재되어 있는 성장인자들이 모발 생성 및 성장 촉진에 관여한다는 가설을 수립하게 되었고, 이 가설을 임상적 연구 결과를 토대로 검증하는 것이 본 연구의 목적이다. 2010년 10월부터 2011년 11월까지 한양대학교 서울병원 성형외과에 내원한 부분탈모로 PRP 주사치료를 받았던 4명의 환자를 대상으로 연구를 시행하였으며, 차트 검토, 환자와의 면담 및 모발 사진 촬영 등을 이용하여 자료를 수집하였다. 환자의 자가 혈액을 필요한 PRP 용량에 맞춰 미리 채혈하고, 채혈된 혈액을 원심분리 시킨 후 혈액을 정제하여 필요한 자가 PRP를 얻었다. 탈모치료에 있어서 PRP 주사치료의 유효율 평가는 치료 전후 사진비교를 통해 이루어졌으며, 주관적 평가(모발의 수와 두께에 대한 환자 만족도 평가)와 객관적 평가(단위 면적 당 모발의 수, 한 모낭 당 다발 모발의 수)로 구분하여 이루어졌다. 환자의 자가 평가에서 4명 환자 모두 시술 후 모발의 수 및 두께에 대해서 탈모가 개선되었다고 평가하였다. 객관적 평가에서는 단위 면적(1.0cm2)당 모발의 수는 평균 6.56 증가된 소견을 보였고, 한 모낭당 다발 모발의 수 역시 평균 5.37 증가된 소견을 보였다. 즉, 부분층 탈모 환자의 모발의 성장이 PRP 주입 전에 비해 주입 후 증가 소견을 보였고, 이는 보다 비침습적인 방법만으로도 탈모치료를 효과적으로 할 수 있는 가능성을 제시해 주었다. PRP 주사 치료에 대한 임상적 결과를 통해 탈모 치료에 있어서 PRP 치료의 유용성에 대해 임상적으로 평가하였으며, PRP가 탈모치료 방법으로써 하나의 대안적인 방법이 될 수 있다는 것을 증명할 수 있었다.| The prevalence of alopecia is increasing due to various social and environmental factors. As a result, the need for treatment of alopecia is also increasing. Diverse methods of treatment were introduced but there is no proven therapeutic agent yet. Therefore, a demand for noninvasive, preventive treatment rose sharply and PRP(platelet rich plasma) injection treatment for alopecia was introduced. According to the previous studies, we set up a hypothesis that growth factors included in PRP play a key role in the growth of hair follicles. Verifying this hypothesis based on a clinical study is the purpose of this study. The study was based on 4 patients who visited the department of reconstructive and plastic surgery of Hanyang university seoul hospital from October 2010 to November 2011. Data collection was based on the patient’s chart information, interviewing with the patient and pictures of the patients hair. Blood samples were taken from the patients according to the amount of blood needed for each patient. Then a process of centrifugation was used to separate the PRP from the patient’s blood sample. The evaluation of the effectiveness of PRP injection in the treatment of alopecia was made by comparing the picutres of the patient’s hair, before and after the PRP treatment was made. The evaluation was also made by Subjective evaluation(made by the patient’s thoughts about the thickness and richness of the hair) and Objective evaluation(made by the evaluation of the number of hair per 1.0cm² and the number of hair per hair follicle) separately. As for the subjective evaluation, all 4 patients were satisfied about the PRP injection treatment. As for the objective evaluation, the number of hair per 1.0cm² was increased to 6.56 and the number of hair per hair follicle was also increased to 5.37. As a result, PRP injection in the treatment of partial alopecia was effective and is blazing a trail in the field of noninvasive treatment of alopecia. The effectiveness of PRP injection was evaluated by clinical studies, therefore, PRP injection treatment can be an alternative candidate of treating alopecia.; The prevalence of alopecia is increasing due to various social and environmental factors. As a result, the need for treatment of alopecia is also increasing. Diverse methods of treatment were introduced but there is no proven therapeutic agent yet. Therefore, a demand for noninvasive, preventive treatment rose sharply and PRP(platelet rich plasma) injection treatment for alopecia was introduced. According to the previous studies, we set up a hypothesis that growth factors included in PRP play a key role in the growth of hair follicles. Verifying this hypothesis based on a clinical study is the purpose of this study. The study was based on 4 patients who visited the department of reconstructive and plastic surgery of Hanyang university seoul hospital from October 2010 to November 2011. Data collection was based on the patient’s chart information, interviewing with the patient and pictures of the patients hair. Blood samples were taken from the patients according to the amount of blood needed for each patient. Then a process of centrifugation was used to separate the PRP from the patient’s blood sample. The evaluation of the effectiveness of PRP injection in the treatment of alopecia was made by comparing the picutres of the patient’s hair, before and after the PRP treatment was made. The evaluation was also made by Subjective evaluation(made by the patient’s thoughts about the thickness and richness of the hair) and Objective evaluation(made by the evaluation of the number of hair per 1.0cm² and the number of hair per hair follicle) separately. As for the subjective evaluation, all 4 patients were satisfied about the PRP injection treatment. As for the objective evaluation, the number of hair per 1.0cm² was increased to 6.56 and the number of hair per hair follicle was also increased to 5.37. As a result, PRP injection in the treatment of partial alopecia was effective and is blazing a trail in the field of noninvasive treatment of alopecia. The effectiveness of PRP injection was evaluated by clinical studies, therefore, PRP injection treatment can be an alternative candidate of treating alopecia.