According to this thesis, a detailed, nonlinear three-dimensional finite element model of lower cervical spinal segment C3–C6 was developed. Computed tomography (CT) data were used to define the three-dimensional bony anatomy of the C3 ~ C6 vertebra. The biomechanical responses of the finite element model were validated with previously published experimental values and existing finite element models under various loading conditions, and the mechanical responses matched reasonably well with experimental and numerical data. This validated finite element model was used to predict the effects of an artificial disc. The Range of Motion (ROM) at each segment and each ligament force were evaluated both in the intact condition and in the treated condition (after implanting the artificial disc), and the analysis results were compared with each other. The compression and rotation stiffness of M6-C artificial disc were also calculated. These results may supplement experimental research in understanding the clinical biomechanics of the human cervical spine and offer an insight and better understanding about the biomechanical effects of the artificial disc.