Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2020-03-03T01:43:17Z | - |
dc.date.available | 2020-03-03T01:43:17Z | - |
dc.date.issued | 2004-02 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v. 36, No. 1, Page. 78-84 | en_US |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://search.proquest.com/docview/1800521876?accountid=11283 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/132055 | - |
dc.description.abstract | Methyl-β-cyclodextrin, a cyclic oligosaccharide known for its interaction with the plasma membrane induces several events in cells including cell growth and anti-tumor activity. In this study, we have investigated the possible role of cyclooxygenase 2 (COX-2) in cell growth arrest induced by methyl-βcyclodextrin in Raw264.7 macrophage cells. Methylβ-cyclodextrin inhibited cell growth and arrested the cell cycle, and this cell cycle arrest reduced the population of cells in the S phase, and concomitantly reduced cyclin A and D expressions. Methyl-β-cyclodextrin in a dose- and time-dependent manner, also induced COX-2 expression, prostaglandin E2 (PGE2) synthesis, and COX-2 promoter activity. Pretreatment of cells with NS398,a COX-2 specific inhibitor completely blocked PGE2 synthesis induced by methyl-β-cyclodextrin, however inhibition on cell proliferation and cell cycle arrest was not effected, suggesting nonassociation of CO X-2 in the cell cycle arrest. These results suggest that methyl-β-cyclodextrin induced cell growth inhibition and cell cycle arrest in Raw264.7 cells may be mediated by cyclin A and D1 expression. | en_US |
dc.description.sponsorship | This work was supported by research grant of Advanced Research Center in Yeungnam University. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | en_US |
dc.subject | cyclin A | en_US |
dc.subject | cyclin D1 | en_US |
dc.subject | cyclooxygenase-2 | en_US |
dc.subject | methyl-β-cyclodextrin | en_US |
dc.title | Methyl-[beta]-cyclodextrin inhibits cell growth and cell cycle arrest via a prostaglandin E(2) independent pathway | en_US |
dc.type | Article | en_US |
dc.relation.volume | 36 | - |
dc.identifier.doi | 10.1038/emm.2004.11 | - |
dc.relation.page | 78-84 | - |
dc.relation.journal | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.contributor.googleauthor | Choi, Young-Ae | - |
dc.contributor.googleauthor | Chin, Byung Rho | - |
dc.contributor.googleauthor | Rhee, Dong Hoon | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.contributor.googleauthor | Chang, Hyeun-W ook | - |
dc.contributor.googleauthor | Kim, Jung-Hye | - |
dc.contributor.googleauthor | Baek, Suk-Hwan | - |
dc.relation.code | 2009210380 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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