Total synthesis of (±)-α-Lycorane via Diels – Alder Reaction of 3,5-Dibromo-2-pyrone
- Title
- Total synthesis of (±)-α-Lycorane via Diels – Alder Reaction of 3,5-Dibromo-2-pyrone
- Author
- 이상철
- Advisor(s)
- 조천규
- Issue Date
- 2014-02
- Publisher
- 한양대학교
- Degree
- Master
- Abstract
- We have launched a new efficient synthetic route to (±)-α-Lycorane by utilizing the Diels-Alder reaction of 3,5-dibromo-2-pyrone.
In summary, We have launched a new efficient synthetic route to (±)-α-Lycorane by utilizing the Diels-Alder reaction of 3,5-dibromo-2-pyrone. The endo-cycloadduct of 3,5-dibromo-2-pyrone with styrene-type dienophile provided the pivotal intermediates for the synthesis of the titled natural alkaloids. The key steps are Diels-Alder reaction, Eschenmoser-Claisen rearrangement and Curtius rearrangement. The total yield is 23.2% over 10 steps.
- URI
- https://repository.hanyang.ac.kr/handle/20.500.11754/130972http://hanyang.dcollection.net/common/orgView/200000423434
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > CHEMISTRY(화학과) > Theses (Master)
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