키랄 페로센을 포함한 포스포아미다이트 리간드의 합성과 올레핀의 비대칭 수소화 규소 첨가반응

Abstract

Palladium-catalyzed asymmetric hydrosilylation of styrene has become a potent methodology to show their efficiencies of newly-developed chiral monodentate phosphorous ligands.1 A significant improvement for catalytic activity and enantioselectivity in the hydrosilylation of styrenes was achieved by chiral monophosphine (MOP) ligands based on the 2-diphenylphosphino-1,1’-binaphthyl skeleton.2 Herein, we report a palladium-catalyzed asymmetric hydrosilylation of styrene with trichlorosilane using chiral phosphoramidites derived from (S)-3,3’-disubstituted 1,1’-binaphthols and secondary amino ferrocene. Optically active organosilanes were transformed to alcohol by a stereospecific oxidative cleavage of the C-Si bond with retention of configuration.

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