차풀과 개다래의 flavonoid 성분 및free radical소거 작용
- Title
- 차풀과 개다래의 flavonoid 성분 및free radical소거 작용
- Other Titles
- Flavonoids from Chamaecrista nomame and Actinidia polygama and their free radical scavenging activities
- Author
- 아메드샤시에드
- Alternative Author(s)
- AhmedShahSyed
- Advisor(s)
- Chul Young Kim
- Issue Date
- 2017-02
- Publisher
- 한양대학교
- Degree
- Doctor
- Abstract
- Flavonoids from Chamaecrista nomame and Actinidia polygama and their free radical scavenging activities
Ahmed Shah Syed
College of Pharmacy
The Graduate School
Hanyang University
In the search of new chemical compounds from nature with expectation of having profound biological activities, two plants namely Chamaecrista nomame and Actinidia polygama were phytochemically investigated. From their methanolic extract, 48 compounds were isolated through various types of chromatographic techniques. The chemical structures of isolated compounds were elucidated using different analytical methods like UV-VIS, Mass, IR, 1D, 2D NMR spectroscopy and polarimetry. Among isolated compounds, four compounds are new, named as isocassiaoccidentalin B (CN-8), nomaminoside (CN-22) obtained from C. nomame and 1-ketodehydroiridodial (AP-1), kaempferol 3-O-[α-L-rhamnopyranosyl (1→3)-(4-O-acetyl)-O-α-L-rhamnopyranosyl(1→6)-(2-O-acetyl)-O-β-galactopyranoside (AP-18) were isolated from A. polygama. The phytochemical groups of compounds isolated from C. nomame are flavanone glycoside (CN-1), flavanone (CN-7), phenyl propanoids (CN-2, CN-4, CN-24), phenyl propanoids glycosides (CN-17, CN-18), chalcone (CN-11), chalcone glycosides (CN-5, CN-21), anthraquinones (CN-13, CN-14, CN-15), flavonol (CN-23), isoflavone (CN-25), flavone (CN-12), and flavone glycosides (CN-3, CN-6, CN-8, CN-9, CN-10, CN-12, CN-18 ̶ CN-20, CN-22). Compounds CN-3,
xii
CN-5, CN-11 were potent free radical scavenger, however compounds CN-13, CN-14, CN-15 and CN-25 expressed weak free radical scavenging activity measured by DPPH and ABTS assays. Nitric oxide release was significantly inhibited by compounds CN-12, CN-7 and CN-3 with negligible damage of cells, while compounds CN-4, CN-6, CN-8, CN- 13, CN-20, CN-22 were found inactive of nitric oxide inhibition. Compounds isolated from methanolic extract of A. polygama are iridoid (AP-1), phenolic acids (AP-2, AP-6, AP-7, AP-11, AP-12), phenyl propanoids (AP-6, AP-13, AP-22), norisoprenoid (AP-3) , coumarin (AP-4), chromene (AP-5), neolignans (AP-10, AP-19), flavanone (AP-8), flavonol (AP-9), flavone glycoside (AP-23) and flavonol glycosides (AP-14 ̶ 18, AP-20, AP-21). Compound AP-13 and AP-14 showed significant free radical scavenging activity in both DPPH and ABTS assays.
Key words: Chamaecrista nomame, Actinidia polygama, flavonoids, structural elucidation, free radical scavenging activities.
- URI
- https://repository.hanyang.ac.kr/handle/20.500.11754/124476http://hanyang.dcollection.net/common/orgView/200000430534
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > PHARMACY(약학과) > Theses (Ph.D.)
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