Studies toward total synthesis of (-)-platensimycin by internal H-bonding mediated intramolecular Diels-Alder reaction
- Title
- Studies toward total synthesis of (-)-platensimycin by internal H-bonding mediated intramolecular Diels-Alder reaction
- Other Titles
- 분자내 딜스-알더 반응을 이용한 (-)-platensimycin의 전합성에 대한 연구
- Author
- 김효미
- Alternative Author(s)
- 김효미
- Advisor(s)
- 조천규
- Issue Date
- 2020-02
- Publisher
- 한양대학교
- Degree
- Master
- Abstract
- We have studied 3,5-dibromo-2-pyrone towards target-oriented synthesis, utilizing its peculiar reactivity as a neutral diene and the selective maneuverability of the two bromine groups. Such efforts have resulted in successful syntheses of an array of biologically important natural products.
Inspired by our recent success on internal hydrogen bonding mediated intramolecular Diels-Alder (IMDA) reaction, we have launched a program inventing a new route that allows an efficient asymmetric synthesis of (-)-platensimycin. The key transformations include C3 selective Sonogashira coupling of 3,5-dibromo-2-pyrone, chemoselective hydrogenation and π-facial selective IMDA cyclization. Presented herein are the results so far and future direction toward total synthesis of (-)-platensimycin.
- URI
- https://repository.hanyang.ac.kr/handle/20.500.11754/123914http://hanyang.dcollection.net/common/orgView/200000437073
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > THEATER & FILM(연극영화학과) > Theses (Master)
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML