Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이성온 | - |
dc.date.accessioned | 2019-12-12T01:29:44Z | - |
dc.date.available | 2019-12-12T01:29:44Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | CURRENT BIOLOGY, v. 29, No. 20, Page. 3386-3401 | en_US |
dc.identifier.issn | 0960-9822 | - |
dc.identifier.issn | 1879-0445 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0960982219310371 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/121257 | - |
dc.description.abstract | Low-intensity, low-frequency ultrasound (LILFU) is the next-generation, non-invasive brain stimulation technology for treating various neurological and psychiatric disorders. However, the underlying cellular and molecular mechanism of LILFU-induced neuromodulation has remained unknown. Here, we report that LILFU-induced neuromodulation is initiated by opening of TRPA1 channels in astrocytes. The Ca2+ entry through TRPA1 causes a release of gliotransmitters including glutamate through Best1 channels in astrocytes. The released glutamate activates NMDA receptors in neighboring neurons to elicit action potential firing. Our results reveal an unprecedented mechanism of LILFU-induced neuromodulation, involving TRPA1 as a unique sensor for LILFU and glutamate-releasing Best1 as a mediator of glia-neuron interaction. These discoveries should prove to be useful for optimization of human brain stimulation and ultrasonogenetic manipulations of TRPA1. | en_US |
dc.description.sponsorship | This work was supported by grants from National Council of Science & Technology (NST) of Korea (no. CRC-15-04-KIST); National Research Foundation (NRF) of Korea (NRF-2018M3C7A1056897); KBRI basic research program through Korea Brain Research Institute funded by Ministry of Science and ICT (18-BR-03-02); and Institute for Basic Science (IBS), Center for Cognition and Society (IBS-R001-D2). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | CELL PRESS | en_US |
dc.subject | ultrasound | en_US |
dc.subject | neuromodulation | en_US |
dc.subject | TRPA1 | en_US |
dc.subject | Best1 | en_US |
dc.subject | NMDAR | en_US |
dc.subject | glutamate | en_US |
dc.title | Ultrasonic Neuromodulation via Astrocytic TRPA1 | en_US |
dc.type | Article | en_US |
dc.relation.no | 20 | - |
dc.relation.volume | 29 | - |
dc.identifier.doi | 10.1016/j.cub.2019.08.021 | - |
dc.relation.page | 3386-3401 | - |
dc.relation.journal | CURRENT BIOLOGY | - |
dc.contributor.googleauthor | Oh, Soo-Jin | - |
dc.contributor.googleauthor | Lee, Jung Moo | - |
dc.contributor.googleauthor | Kim, Hyun-Bum | - |
dc.contributor.googleauthor | Lee, Jungpyo | - |
dc.contributor.googleauthor | Han, Sungmin | - |
dc.contributor.googleauthor | Bae, Jin Young | - |
dc.contributor.googleauthor | Hong, Gyu-Sang | - |
dc.contributor.googleauthor | Koh, Wuhyun | - |
dc.contributor.googleauthor | Kwon, Jea | - |
dc.contributor.googleauthor | Hwang, Eun-Sang | - |
dc.contributor.googleauthor | Woo, Dong Ho | - |
dc.contributor.googleauthor | Youn, Inchan | - |
dc.contributor.googleauthor | Cho, Il-Joo | - |
dc.contributor.googleauthor | Bae, Yong Chul | - |
dc.contributor.googleauthor | Lee, Sungon | - |
dc.contributor.googleauthor | Shim, Jae Wan | - |
dc.contributor.googleauthor | Park, Ji-Ho | - |
dc.contributor.googleauthor | Lee, C. Justin | - |
dc.relation.code | 2019001885 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF ENGINEERING SCIENCES[E] | - |
dc.sector.department | DIVISION OF ELECTRICAL ENGINEERING | - |
dc.identifier.pid | sungon | - |
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