RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent
- Title
- RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent
- Author
- 이민형
- Keywords
- Anti-angiogenesis; Gene delivery; Glioblastoma; Polyethylenimine; RAGE-binding peptide
- Issue Date
- 2018-11
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 67, page. 284-292
- Abstract
- Receptor for advanced glycation end-products (RAGE) is overexpressed in various cancer cells. In this study, a RAGE-binding peptide (RBP) was conjugated to polyethylenimine (25 kDa, PEI). RBP-conjugated PEI (PEI-RBP) was characterized as a dual-functional reagent, a RAGE-mediated gene carrier and an anti-angiogenic reagent. As a gene carrier, PEI-RBP had higher transfection efficiency to the C6 glioblastoma cells than PEI. As an anti-angiogenic reagent, the pEmpty/PEI-RBP complex reduced RAGE expression on the surface of the C6 glioblastoma cells. Also, the complex reduced the VEGF expression and tube formation of endothelial cells. Therefore, PEI-RBP may be useful for development of glioblastoma therapy. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S1226086X18303319?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/120522
- ISSN
- 1226-086X; 1876-794X
- DOI
- 10.1016/j.jiec.2018.06.040
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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