Hovenia dulcis Extract Attenuates High-Fat Diet-Induced Hepatic Lipid Accumulation and Hypertriglyceridemia in C57BL/6 Mice
- Title
- Hovenia dulcis Extract Attenuates High-Fat Diet-Induced Hepatic Lipid Accumulation and Hypertriglyceridemia in C57BL/6 Mice
- Author
- 고광웅
- Keywords
- antioxidant enzymes; hepatic lipid accumulation; Hovenia dulcis Thunb. extract; hyperlipidemia
- Issue Date
- 2018-11
- Publisher
- MARY ANN LIEBERT
- Citation
- JOURNAL OF MEDICINAL FOOD, v. 22, no. 1, page. 74-80
- Abstract
- The effects of dietary supplementation with aqueous Hovenia dulcis Thunb. extract (HDE) (20 weeks) on high-fat diet (HFD)-induced nonalcoholic fatty liver disease and dyslipidemia were evaluated in mice. Supplementation with 200 and 800 mg/kg feed HDE (HDE200 and HDE800, respectively) resulted in no significant difference in growth in the HFD-fed groups. The triglyceride (TG) levels and free fatty acids were significantly decreased, whereas high-density lipoprotein cholesterol was increased in the HDE800 group (P < .05). The hepatic intracellular TGs were significantly decreased in the HDE-fed groups and lipogenic enzymes (acetyl CoA carboxylase, fatty acid synthase, stearoyl CoA desaturase, and diacylglycerol transferase) in the liver were significantly downregulated by HDE supplementation (P < .05). The diminished serum antioxidant enzyme activities in the HFD group were effectively restored by HDE supplementation, which also contributed to the attenuation of hyperlipidemia.
- URI
- https://www.liebertpub.com/doi/10.1089/jmf.2018.4224https://repository.hanyang.ac.kr/handle/20.500.11754/120507
- ISSN
- 1096-620X; 1557-7600
- DOI
- 10.1089/jmf.2018.4224
- Appears in Collections:
- COLLEGE OF HUMAN ECOLOGY[S](생활과학대학) > FOOD & NUTRITION(식품영양학과) > Articles
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