Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2019-12-08T01:32:31Z | - |
dc.date.available | 2019-12-08T01:32:31Z | - |
dc.date.issued | 2018-05 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 8, Article no. 7683 | en_US |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.nature.com/articles/s41598-018-26075-3 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/118624 | - |
dc.description.abstract | The cholinergic system arising from the basal forebrain plays an important role in cognitive performance in Parkinson's disease (PD). Here, we analyzed cholinergic status-dependent cortical and subcortical resting-state functional connectivity in PD. A total of 61 drug-naive PD patients were divided into tertiles based on normalized substantia innominata (SI) volumes. We compared the restingstate network from seed region of interest in the caudate, posterior cingulate cortex (PCC), and SI between the lowest (PD-L) and highest tertile (PD-H) groups. Correlation analysis of the functional networks was also performed in all subjects. The functional network analysis showed that PD-L subjects displayed decreased striato-cortical functional connectivity compared with PD-H subjects. Selecting the PCC as a seed, the PD-L patients displayed decreased functional connectivity compared to PD-H patients. Meanwhile, PD-L subjects had significantly increased cortical functional connectivity with the SI compared with PD-H subjects. Correlation analysis revealed that SI volume had a positive correlation with functional connectivity from the right caudate and PCC. The present study demonstrated that PD patients exhibited unique functional connectivity from the caudate and the PCC that may be closely associated with cholinergic status, suggesting an important role for the cholinergic system in PDassociated cognition. | en_US |
dc.description.sponsorship | This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C1118). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | MILD COGNITIVE IMPAIRMENT | en_US |
dc.subject | DEFAULT-MODE NETWORK | en_US |
dc.subject | MULTIPLE-SYSTEM ATROPHY | en_US |
dc.subject | DIAGNOSTIC-CRITERIA | en_US |
dc.subject | CINGULATE CORTEX | en_US |
dc.subject | BASAL FOREBRAIN | en_US |
dc.subject | HUMAN BRAIN | en_US |
dc.subject | CONNECTIVITY | en_US |
dc.subject | DEMENTIA | en_US |
dc.subject | MRI | en_US |
dc.title | The cholinergic contribution to the resting-state functional network in non-demented Parkinson's disease | en_US |
dc.type | Article | en_US |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.1038/s41598-018-26075-3 | - |
dc.relation.page | 1-10 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Lee, Yoonju | - |
dc.contributor.googleauthor | Ham, Jee Hyun | - |
dc.contributor.googleauthor | Cha, Jungho | - |
dc.contributor.googleauthor | Park, Yeong-Hun | - |
dc.contributor.googleauthor | Lee, Jae Jung | - |
dc.contributor.googleauthor | Sunwoo, Mun Kyung | - |
dc.contributor.googleauthor | Hong, Jin Yong | - |
dc.contributor.googleauthor | Sohn, Young H. | - |
dc.contributor.googleauthor | Lee, Jong-Min | - |
dc.contributor.googleauthor | Lee, Phil Hyu | - |
dc.relation.code | 2018003596 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
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