Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조성신 | - |
dc.date.accessioned | 2019-12-07T19:10:22Z | - |
dc.date.available | 2019-12-07T19:10:22Z | - |
dc.date.issued | 2018-04 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v. 50, Article no. e455 | en_US |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.issn | 2092-6413 | - |
dc.identifier.uri | https://www.nature.com/articles/emm2017289 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/118325 | - |
dc.description.abstract | Transient receptor potential vanilloid 1 (TRPV1) affects mood and neuroplasticity in the brain, where its role is poorly understood. In the present study we investigated whether capsaicin (8-methyl-N-vanillyl-trans-6-nonenamide), an agonist of TRPV1, induced chromatin remodeling and thereby altered gene expression related to synaptic plasticity. We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters. Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression. Taken together, our findings implicate HDAC2 in capsaicin-induced transcriptional regulation of synaptic molecules and support the view that HDAC2 is a molecular link between TRPV1 activity and synaptic plasticity. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (HY-2017), a grant from the Medical Research Center (NRF-2017R1A5A2015395), and Basic Science Research Program though the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2016R1A2B2006474, 2017R1A6A3A01005765). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | MEMORY FORMATION | en_US |
dc.subject | NMDA RECEPTORS | en_US |
dc.subject | DENTATE GYRUS | en_US |
dc.subject | HIPPOCAMPUS | en_US |
dc.subject | RAT | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | BEHAVIORS | en_US |
dc.subject | PAIN | en_US |
dc.subject | NEUROGENESIS | en_US |
dc.subject | INDUCTION | en_US |
dc.title | Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/emm.2017.289 | - |
dc.relation.page | 455-455 | - |
dc.relation.journal | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.contributor.googleauthor | Wang, Sung Eun | - |
dc.contributor.googleauthor | Ko, Seung Yeon | - |
dc.contributor.googleauthor | Kim, Yong-Seok | - |
dc.contributor.googleauthor | Jo, Sungsin | - |
dc.contributor.googleauthor | Lee, Seung Hoon | - |
dc.contributor.googleauthor | Jung, Sung Jun | - |
dc.contributor.googleauthor | Son, Hyeon | - |
dc.relation.code | 2018009510 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | RHEUMATISM CENTER | - |
dc.identifier.pid | joejo0517 | - |
dc.identifier.orcid | http://orcid.org/0000-0003-3034-5029 | - |
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