Overexpression of Forkhead Box O3a and Its Association With Aggressive Phenotypes and Poor Prognosis in Human Hepatocellular Carcinoma
- Title
- Overexpression of Forkhead Box O3a and Its Association With Aggressive Phenotypes and Poor Prognosis in Human Hepatocellular Carcinoma
- Author
- 백승삼
- Keywords
- Forkhead box O3A protein (FoxO3A); Hepatocellular carcinoma; Immunohistochemistry; Prognosis
- Issue Date
- 2018-02
- Publisher
- OXFORD UNIV PRESS INC
- Citation
- AMERICAN JOURNAL OF CLINICAL PATHOLOGY, v. 149, no. 2, page. 117-127
- Abstract
- Objectives: Recent research has demonstrated that forkhead box O3a (FoxO3a) may function as an oncogenic transcription factor. We sought to validate the clinicopathologic significance of FoxO3a expression in hepatocellular carcinoma (HCC).Methods: Western blotting and immunohistochemistry were used to determine FoxO3a expression. In vitro cell proliferation and migration assays were performed in a HepG2 cell line.Results: FoxO3a was overexpressed in 121 (64.71%) cases of HCC. FoxO3a overexpression was associated with aggressive phenotypes of HCC, such as histologic grade (P < .001), stage (P = .031), and small vessel invasion (P < .001). FoxO3a overexpression was also correlated with poor disease-free survival in both univariate and multivariate survival analyses (P = .001 and P = .018, respectively). Downregulation of FoxO3a in a HepG2 cell line inhibited cell proliferation and migration.Conclusions: These results suggest a role for FoxO3a in HCC progression and support the potential use as a prognostic biomarker.
- URI
- https://academic.oup.com/ajcp/article/149/2/117/4818474https://repository.hanyang.ac.kr/handle/20.500.11754/117382
- ISSN
- 0002-9173; 1943-7722
- DOI
- 10.1093/AJCP/AQX132
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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