Clinical risk stratification model for advanced colorectal neoplasia in persons with negative fecal immunochemical test results
- Title
- Clinical risk stratification model for advanced colorectal neoplasia in persons with negative fecal immunochemical test results
- Author
- 박찬혁
- Keywords
- CANCER INCIDENCE; COLONOSCOPY; ATHEROSCLEROSIS; SIGMOIDOSCOPY; POPULATION; INDEX; ASIA
- Issue Date
- 2018-01
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v. 13, no. 1, Article no. e0191125
- Abstract
- ObjectivesThe fecal immunochemical test (FIT) has low sensitivity for detecting advanced colorectal neoplasia (ACRN); thus, a considerable portion of FIT-negative persons may have ACRN. We aimed to develop a risk-scoring model for predicting ACRN in FIT-negative persons.Materials and methodsWe reviewed the records of participants aged >= 40 years who underwent a colonoscopy and FIT during a health check-up. We developed a risk-scoring model for predicting ACRN in FIT-negative persons.ResultsOf 11,873 FIT-negative participants, 255 (2.1%) had ACRN. On the basis of the multivariable logistic regression model, point scores were assigned as follows among FIT-negative persons: age (per year from 40 years old), 1 point; current smoker, 10 points; overweight, 5 points; obese, 7 points; hypertension, 6 points; old cerebrovascular attack (CVA), 15 points. Although the proportion of ACRN in FIT-negative persons increased as risk scores increased (from 0.6% in the group with 0-4 points to 8.1% in the group with 35-39 points), it was significantly lower than that in FIT-positive persons (14.9%). However, there was no statistical difference between the proportion of ACRN in FIT-negative persons with >= 40 points and in FIT-positive persons (10.5% vs. 14.9%, P = 0.321).ConclusionsFIT-negative persons may need to undergo screening colonoscopy if they clinically have a high risk of ACRN. The scoring model based on age, smoking habits, overweight or obesity, hypertension, and old CVA may be useful in selecting and prioritizing FIT-negative persons for screening colonoscopy.
- URI
- https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191125https://repository.hanyang.ac.kr/handle/20.500.11754/117265
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0191125
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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