Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice
- Title
- Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice
- Author
- 손현
- Keywords
- MEMORY FORMATION; NMDA RECEPTORS; DENTATE GYRUS; HIPPOCAMPUS; RAT; EXPRESSION; BEHAVIORS; PAIN; NEUROGENESIS; INDUCTION
- Issue Date
- 2018-01
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- EXPERIMENTAL AND MOLECULAR MEDICINE, v. 50, Article no. e455
- Abstract
- Transient receptor potential vanilloid 1 (TRPV1) affects mood and neuroplasticity in the brain, where its role is poorly understood. In the present study we investigated whether capsaicin (8-methyl-N-vanillyl-trans-6-nonenamide), an agonist of TRPV1, induced chromatin remodeling and thereby altered gene expression related to synaptic plasticity. We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters. Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression. Taken together, our findings implicate HDAC2 in capsaicin-induced transcriptional regulation of synaptic molecules and support the view that HDAC2 is a molecular link between TRPV1 activity and synaptic plasticity.
- URI
- https://www.nature.com/articles/emm2017289https://repository.hanyang.ac.kr/handle/20.500.11754/117094
- ISSN
- 1226-3613; 2092-6413
- DOI
- 10.1038/emm.2017.289
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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