Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-12-03T00:18:35Z | - |
dc.date.available | 2019-12-03T00:18:35Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v. 304, Page. 7-18 | en_US |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.issn | 1873-4995 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0168365919302366 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/116546 | - |
dc.description.abstract | Gold nanoclusters (AuNCs) are viewed as effective hyperthermal agents for the treatment of tumors. Whereas AuNCs formed by the agglomeration of several to tens of gold atoms (< 1-2 nm) possess significant fluorescence, they have a negligible hyperthermal effect, while AuNCs comprised of spherical gold nanoparticles (AuNPs > a few nanometers) have a marked hyperthermic effect but lose their inherent fluorescence and obstruct the intensity of neighboring fluorescent dyes due to Forster resonance energy transfer (FRET). To achieve both hyperthermia and fluorescence-based optical visualization, we generated hybrid albumin nanoparticles containing AuNCs (similar to 88 nm) comprising AuNPs (similar to 4.5 nm). We generated a series of formulated AuNCs and optimized the size, morphology, NIR absorbance (600-900 nm), hyperthermal activity, and fluorescence spectral characters of the resulting hybrid albumin nanoparticles (AuNCs/BSA-NPs) by considering the interparticle distance between the AuNPs and Cy5.5. Among these, AuNCs/BSA-NPs (formula D) had a strong hyperthermic effect and had well-preserved fluorescence intensity (from the attached Cy5.5) due to localized surface plasmon resonance (LSPR) and a reduction in FRET. These AuNCs/BSA-NPs were able to elevate the surface tumor temperature of HCT116-bearing mice to >50 degrees C following 808 nm laser irradiation (1.5 W/cm(2), 10 min), which remarkably suppressed tumor growth (17.8 +/- 16.9 mm(3) vs. PBS and AuNCs/BSA-NPs (formula E): similar to 1850 and similar to 1250 mm(3), respectively). Also, Cy5.5-modified AuNCs/BSA-NPs (formula D) showed good performance in optical fluorescence imaging of target tumors in HCT116 tumor-bearing mice. Together, our results indicate that the interparticle distance between albumin or Cy5.5 and AuNPs/AuNCs can be optimized to achieve both hyperthermia and fluorescence emission by striking a balance between LSPR and FRET effects. We believe that the AuNC/BSA-NPs formulation presented here can serve as a potential platform for both optically visualizing and treating colon cancers. | en_US |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2017R1A2B2004955). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Gold nanoclusters | en_US |
dc.subject | Albumin nanoparticles | en_US |
dc.subject | Hyperthermia | en_US |
dc.subject | LSPR | en_US |
dc.subject | FRET | en_US |
dc.subject | Antitumor therapy | en_US |
dc.title | Gold nanocluster-loaded hybrid albumin nanoparticles with fluorescence-based optical visualization and photothermal conversion for tumor detection/ablation | en_US |
dc.type | Article | en_US |
dc.relation.volume | 308 | - |
dc.identifier.doi | 10.1016/j.jconrel.2019.04.036 | - |
dc.relation.page | 7-18 | - |
dc.relation.journal | JOURNAL OF CONTROLLED RELEASE | - |
dc.contributor.googleauthor | Park, Sanghyun | - |
dc.contributor.googleauthor | Kim, Hanju | - |
dc.contributor.googleauthor | Lim, Su Chan | - |
dc.contributor.googleauthor | Lim, Kyungseop | - |
dc.contributor.googleauthor | Lee, Eun Seong | - |
dc.contributor.googleauthor | Oh, Kyung Taek | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.contributor.googleauthor | Youn, Yu Seok | - |
dc.relation.code | 2019002890 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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