Zika virus directly infects peripheral neurons and induces cell death
- Title
- Zika virus directly infects peripheral neurons and induces cell death
- Author
- 오요한
- Keywords
- EMBRYONIC STEM-CELLS; NEURAL CREST CELLS; IDENTIFICATION; PROGENITORS; DERIVATION; EXPOSURE; MODELS; BRAIN
- Issue Date
- 2017-09
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE NEUROSCIENCE, v. 20, no. 9, page. 1209-1212
- Abstract
- Zika virus (ZIKV) infection is associated with neurological disorders of both the CNS and peripheral nervous systems (PNS), yet few studies have directly examined PNS infection. Here we show that intraperitoneally or intraventricularly injected ZIKV in the mouse can infect and impact peripheral neurons in vivo. Moreover, ZIKV productively infects stemcell- derived human neural crest cells and peripheral neurons in vitro, leading to increased cell death, transcriptional dysregulation and cell-type-specific molecular pathology.
- URI
- https://www.nature.com/articles/nn.4612https://repository.hanyang.ac.kr/handle/20.500.11754/115726
- ISSN
- 1097-6256; 1546-1726
- DOI
- 10.1038/nn.4612
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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