Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고광웅 | - |
dc.date.accessioned | 2019-11-27T20:57:54Z | - |
dc.date.available | 2019-11-27T20:57:54Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.citation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 27, no. 4, page. 660-667 | en_US |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.issn | 1738-8872 | - |
dc.identifier.uri | http://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1612.12037 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/115016 | - |
dc.description.abstract | PineXol, extracted from Korean red pine bark, has beneficial effects, such as antioxidant, anti-inflammatory, and antilipogenic activities in vitro. We tested the hypothesis that PineXol supplementation could have anti-obesity effects on mice fed a high-fat diet (HFD). Four-weekold male C57BL/6 mice were fed normal chow (18% kcal from fat) or a HFD (60% kcal from fat). HFD-fed animals were also subjected to PineXol treatment at a dose of 10 or 50 mg/kg body weight (BW) (PX10 or PX50, respectively) body weight. The body weight and body fat mass in the PX50 group were statistically lower than those in the HFD group (p < 0.05 and p < 0.001, respectively). The concentration of hepatic triglycerides, total cholesterol, and low-density lipoprotein cholesterol were reduced in the PX50 group compared with the HFD group (p < 0.01). Acetyl CoA carboxylase (p < 0.01), elongase of very long chain fatty acids 6 (p < 0.01), stearoyl CoA desaturase 1 (p < 0.05), microsomal triglyceride transfer protein (p < 0.01), and sterol regulatory element-binding protein 1 (p < 0.05) were significantly decreased in the PX50 group compared with that in the HFD group. In white adipose tissue, CCAAT-enhancer-binding protein alpha (p < 0.05), peroxisome proliferator-activated receptor gamma (p < 0.001), and perilipin (p < 0.01) were decreased in the PX50 group compared with those in the HFD group. Therefore, the current study implies the potential of PineXol for the prevention and/or amelioration of obesity, in part by inhibition of both hepatic lipid synthesis and adipogenesis in white adipose tissue. | en_US |
dc.description.sponsorship | This work was supported by the Food Functionality Evaluation Program under the Ministry of Agriculture, Food and Rural Affairs and partly the Korea Food Research Institute. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN SOC MICROBIOLOGY &amp; BIOTECHNOLOGY | en_US |
dc.subject | PineXol | en_US |
dc.subject | anti-obesity | en_US |
dc.subject | hepatic lipogenesis | en_US |
dc.subject | adipogenesis | en_US |
dc.title | Pinus Densiflora Bark Extract (PineXol) Decreases Adiposity in Mice by Down-Regulation of Hepatic De Novo Lipogenesis and Adipogenesis in White Adipose Tissue | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 27 | - |
dc.identifier.doi | 10.4014/jmb.1612.12037 | - |
dc.relation.page | 660-667 | - |
dc.relation.journal | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.contributor.googleauthor | Ahn, Hyemyoung | - |
dc.contributor.googleauthor | Go, Gwang-woong | - |
dc.relation.code | 2017006201 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | gwgo1015 | - |
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