고광웅
2019-11-27T20:57:54Z
2019-11-27T20:57:54Z
2017-07
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 27, no. 4, page. 660-667
1017-7825
1738-8872
http://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1612.12037
https://repository.hanyang.ac.kr/handle/20.500.11754/115016
PineXol, extracted from Korean red pine bark, has beneficial effects, such as antioxidant, anti-inflammatory, and antilipogenic activities in vitro. We tested the hypothesis that PineXol supplementation could have anti-obesity effects on mice fed a high-fat diet (HFD). Four-weekold male C57BL/6 mice were fed normal chow (18% kcal from fat) or a HFD (60% kcal from fat). HFD-fed animals were also subjected to PineXol treatment at a dose of 10 or 50 mg/kg body weight (BW) (PX10 or PX50, respectively) body weight. The body weight and body fat mass in the PX50 group were statistically lower than those in the HFD group (p < 0.05 and p < 0.001, respectively). The concentration of hepatic triglycerides, total cholesterol, and low-density lipoprotein cholesterol were reduced in the PX50 group compared with the HFD group (p < 0.01). Acetyl CoA carboxylase (p < 0.01), elongase of very long chain fatty acids 6 (p < 0.01), stearoyl CoA desaturase 1 (p < 0.05), microsomal triglyceride transfer protein (p < 0.01), and sterol regulatory element-binding protein 1 (p < 0.05) were significantly decreased in the PX50 group compared with that in the HFD group. In white adipose tissue, CCAAT-enhancer-binding protein alpha (p < 0.05), peroxisome proliferator-activated receptor gamma (p < 0.001), and perilipin (p < 0.01) were decreased in the PX50 group compared with those in the HFD group. Therefore, the current study implies the potential of PineXol for the prevention and/or amelioration of obesity, in part by inhibition of both hepatic lipid synthesis and adipogenesis in white adipose tissue.
This work was supported by the Food Functionality Evaluation Program under the Ministry of Agriculture, Food and Rural Affairs and partly the Korea Food Research Institute.
en_US
KOREAN SOC MICROBIOLOGY &amp; BIOTECHNOLOGY
PineXol
anti-obesity
hepatic lipogenesis
adipogenesis
Pinus Densiflora Bark Extract (PineXol) Decreases Adiposity in Mice by Down-Regulation of Hepatic De Novo Lipogenesis and Adipogenesis in White Adipose Tissue
Article
4
27
10.4014/jmb.1612.12037
660-667
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
Ahn, Hyemyoung
Go, Gwang-woong
2017006201
S
COLLEGE OF HUMAN ECOLOGY[S]
DEPARTMENT OF FOOD & NUTRITION
gwgo1015