Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오성근 | - |
dc.date.accessioned | 2019-11-26T20:38:10Z | - |
dc.date.available | 2019-11-26T20:38:10Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.citation | SKIN PHARMACOLOGY AND PHYSIOLOGY, v. 30, no. 4, page. 190-196 | en_US |
dc.identifier.issn | 1660-5527 | - |
dc.identifier.issn | 1660-5535 | - |
dc.identifier.uri | https://www.karger.com/Article/FullText/477356 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114839 | - |
dc.description.abstract | Background/Aims: Excessive melanogenesis often causes unaesthetic hyperpigmentation. In a previous report, our group introduced a newly synthesized depigmentary agent, Melasolv (TM) (3,4,5-trimethoxycinnamate thymol ester). In this study, we demonstrated the significant whitening efficacy of Melasolv using various melanocytes and human skin equivalents as in vitro experimental systems. Methods: The depigmentary effect of Melasolv was tested in melan-a cells (immortalized normal murine melanocytes), alpha-melanocytestimulating hormone (alpha-MSH)-stimulated B16 murine melanoma cells, primary normal human melanocytes (NHMs), and human skin equivalent (MelanoDerm). The whitening efficacy of Melasolv was further demonstrated by photography, time-lapse microscopy, Fontana-Masson (F&M) staining, and 2-photon microscopy. Results: Melasolv significantly inhibited melanogenesis in the melan-a and alpha-MSH-stimulated B16 cells. In human systems, Melasolv also clearly showed a whitening effect in NHMs and human skin equivalent, reflecting a decrease in melanin content. F&M staining and 2-photon microscopy revealed that Melasolv suppressed melanin transfer into multiple epidermal layers from melanocytes as well as melanin synthesis in human skin equivalent. Conclusion: Our study showed that Melasolv clearly exerts a whitening effect on various melanocytes and human skin equivalent. These results suggest the possibility that Melasolv can be used as a depigmentary agent to treat pigmentary disorders as well as an active ingredient in cosmetics to increase whitening efficacy. (C) 2017 S. Karger AG, Basel | en_US |
dc.description.sponsorship | This research was supported and funded by the Application Technology Research Institute of the Amorepacific R&D Center. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KARGER | en_US |
dc.subject | Melasolv | en_US |
dc.subject | Melanogenesis | en_US |
dc.subject | Depigmentary agent | en_US |
dc.subject | Three-dimensional human skin equivalent | en_US |
dc.title | Antimelanogenic efficacy of melasolv (3,4,5-trimethoxycinnamate thymol ester) in melanocytes and three-dimensional human skin equivalent | en_US |
dc.type | Article | en_US |
dc.relation.volume | 30 | - |
dc.identifier.doi | 10.1159/000477356 | - |
dc.relation.page | 190-196 | - |
dc.relation.journal | SKIN PHARMACOLOGY AND PHYSIOLOGY | - |
dc.contributor.googleauthor | Lee, John Hwan | - |
dc.contributor.googleauthor | Lee, Eun-Soo | - |
dc.contributor.googleauthor | Bae, Il-Hong | - |
dc.contributor.googleauthor | Hwang, Jeong-Ah | - |
dc.contributor.googleauthor | Kim, Se-Hwa | - |
dc.contributor.googleauthor | Kim, Dae-Yong | - |
dc.contributor.googleauthor | Park, Nok-Hyun | - |
dc.contributor.googleauthor | Rho, Ho Sik | - |
dc.contributor.googleauthor | Kim, Yong Jin | - |
dc.contributor.googleauthor | Oh, Seong-Geun | - |
dc.relation.code | 2017002536 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF CHEMICAL ENGINEERING | - |
dc.identifier.pid | seongoh | - |
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