Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 조용우 | - |
dc.date.accessioned | 2019-11-26T06:52:49Z | - |
dc.date.available | 2019-11-26T06:52:49Z | - |
dc.date.issued | 2019-05 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v. 512, No. 3, Page. 511-516 | en_US |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0006291X19304553 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114707 | - |
dc.description.abstract | Cancer stem cells (CSCs) are a small population of cells with stem cell-like properties found in tumors. CSCs are closely associated with tumor heterogeneity, which influences tumor progress, metastasis, and drug resistance. Here, we propose a concept to enhance efficacy of cancer therapy through CSC reprogramming into non-tumorigenic cells using stem cell -derived exosomes with osteoinductive potential. We hypothesized that exosomes derived from osteogenic differentiating human adipose-derived stem cells (0D-EX0s) contain specific cargos capable of inducing osteogenic differentiation of CSCs. Quantitative RT-PCR analysis revealed that OD-EXO5 enhanced the expression of osteogenic-related genes, such as alkaline phosphatase (ALPL), osteocalcin (BGLAP), and runt-related transcription factor 2 (RUNX2). In addition, expression of drug-resistance genes such as ATP binding cassette (ABC) transporter, the breast cancer gene family (BCRA1 and BCRA2), and the ErbB gene family were significantly decreased in OD-EXO-treated CSCs. Our findings suggest that OD-EXOs function as a biochemical cue for CSC reprogramming and contribute to overcoming therapeutic resistance. (C) 2019 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & Id (NRF-2018M3A9H1023767). This research was also supported by the Basic Science Research Program through a National Research Foundation of Korea grant funded by the Korean Government (MEST) (NRF-2017R1A5A1070259). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | en_US |
dc.subject | Exosomes | en_US |
dc.subject | Cancer stem cells | en_US |
dc.subject | Reprogramming | en_US |
dc.subject | Drug resistance | en_US |
dc.title | Reprogramming of cancer stem cells into non-tumorigenic cells using stem cell exosomes for cancer therapy | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 512 | - |
dc.identifier.doi | 10.1016/j.bbrc.2019.03.072 | - |
dc.relation.page | 511-516 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.contributor.googleauthor | Lee, Kyoung Soo | - |
dc.contributor.googleauthor | Choi, Ji Suk | - |
dc.contributor.googleauthor | Cho, Yong Woo | - |
dc.relation.code | 2019001376 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF ENGINEERING SCIENCES[E] | - |
dc.sector.department | DEPARTMENT OF MATERIALS SCIENCE AND CHEMICAL ENGINEERING | - |
dc.identifier.pid | ywcho7 | - |
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