Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유혜현 | - |
dc.date.accessioned | 2019-11-26T06:19:40Z | - |
dc.date.available | 2019-11-26T06:19:40Z | - |
dc.date.issued | 2019-05 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF LEGAL MEDICINE, v. 133, No. 3, Page. 833-841 | en_US |
dc.identifier.issn | 0937-9827 | - |
dc.identifier.issn | 1437-1596 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs00414-018-1904-7 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114674 | - |
dc.description.abstract | 2-(2,5-Dimethoxy-4-nitrophenyl)-N-(2-methoxybenzyl)ethanamine (25N-NBOMe, 2C-N-NBOMe, NBOMe-2C-N) is a novel synthetic psychoactive substance of the phenethylamine chemical class. A few metabolism studies have been conducted for 25I-NBOMe, 25B-NBOMe, and 25C-NBOMe, and others, whereas 25N-NBOMe metabolism has not been researched. In this study, the in vitro metabolism of 25N-NBOMe was investigated with human liver microsomes, and the reaction mixture was analyzed using liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS). Formation of 14 metabolites (M1-M14) was yielded with incubation of 25N-NBOMe in human liver microsomes in the presence of NADPH. The metabolites were structurally characterized on the basis of accurate mass analysis and MS/MS fragmentation patterns. The biotransformations included hydroxylation, O-demethylation, N-dealkylation, nitro reduction, dehydrogenation, carbonylation, and combinations thereof. Hydroxyl metabolite was the most abundant compound after the phase I process. These results provide helpful information establishing biomarkers in case of 25N-NBOMe ingestion. | en_US |
dc.description.sponsorship | This study was supported by the Ministry of Food and Drug Safety of Korea (17181MFDS416). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | 25N-NBOMe | en_US |
dc.subject | Human liver microsomes | en_US |
dc.subject | Metabolism | en_US |
dc.subject | LC-Q-TOF/MS | en_US |
dc.title | Metabolic profile determination of 25N-NBOMe in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometry | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 133 | - |
dc.identifier.doi | 10.1007/s00414-018-1904-7 | - |
dc.relation.page | 833-841 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF LEGAL MEDICINE | - |
dc.contributor.googleauthor | Seo, Hyewon | - |
dc.contributor.googleauthor | Kim, In Sook | - |
dc.contributor.googleauthor | Kim, Young-Hoop | - |
dc.contributor.googleauthor | Yoo, Hye Hyun | - |
dc.contributor.googleauthor | Hong, Jin | - |
dc.relation.code | 2019000788 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | yoohh | - |
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