Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2019-11-25T04:09:09Z | - |
dc.date.available | 2019-11-25T04:09:09Z | - |
dc.date.issued | 2017-05 | - |
dc.identifier.citation | CARBOHYDRATE POLYMERS, v. 164, page. 309-316 | en_US |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.issn | 1879-1344 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0144861717301297?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114035 | - |
dc.description.abstract | The marine mussel-inspired properties of catechol, adhesiveness and cohesiveness, have been applied with pH control to fabricate hollow particles using a silica core and catechol-modified hyaluronic acid (HA-CA) shell for an anticancer drug carrier. The competition between adhesive and cohesive properties of catechol with different pH values leads to various structures, a rough catechol modified HA (HA-CA) shell at pH 5.5, monodisperse spherical silica@HA-CA particles at pH 7.4, and an amorphous HA-CA layer at pH 8.5. The redox transition of catechol with pH is a key factor modulating the behavior of the HA-CA shell on the silica core, which induces strong adhesion of HA-CA to silica at pH 5.5 and structural hardness with cohesive coupling at pH 7.4. In addition, after core removal, the hollow HA-CA particles are followed by loading of anticancer drug, doxorubicin (DOX). DOX loaded HA-CA particles show pH-triggered release behavior and dramatic cytotoxic effect indicating that they are a promising novel anticancer drug carrier. (C) 2017 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by a National Research Foundation of Korea (NRF no. 2015M2B2A9032029). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.subject | Hyaluronic acid | en_US |
dc.subject | Catechol | en_US |
dc.subject | Redox transition | en_US |
dc.subject | Adhesive | en_US |
dc.subject | pH triggered release | en_US |
dc.title | Hollow hyaluronic acid particles by competition between adhesive and cohesive properties of catechol for anticancer drug carrier | en_US |
dc.type | Article | en_US |
dc.relation.volume | 164 | - |
dc.identifier.doi | 10.1016/j.carbpol.2017.02.009 | - |
dc.relation.page | 309-316 | - |
dc.relation.journal | CARBOHYDRATE POLYMERS | - |
dc.contributor.googleauthor | Lee, Jeongwook | - |
dc.contributor.googleauthor | Yoo, Ki Chun | - |
dc.contributor.googleauthor | Ko, Jaehyoung | - |
dc.contributor.googleauthor | Yoo, Bowon | - |
dc.contributor.googleauthor | Shin, Joohuei | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.contributor.googleauthor | Sohn, Daewon | - |
dc.relation.code | 2017002084 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
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