Mitochondrial DNA copy number augments performance of A(1)C and oral glucose tolerance testing in the prediction of type 2 diabetes
- Title
- Mitochondrial DNA copy number augments performance of A(1)C and oral glucose tolerance testing in the prediction of type 2 diabetes
- Author
- 고인송
- Keywords
- FASTING PLASMA-GLUCOSE; PREVALENCE; HBA1C; RISK
- Issue Date
- 2017-03
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v. 7, Article no. 43203
- Abstract
- Here, we tested the performance of the mitochondrial DNA copy number (mtDNA-CN) in predicting future type 2 diabetes (n = 1108). We used the baseline clinical data (age, sex, body mass index, waist-to-hip ratio, systolic and diastolic blood pressure) and the mtDNA-CN, hemoglobin A(1c) (A(1)C) levels and results of oral glucose tolerance test (OGTT) including fasting plasma glucose, 1-hour glucose, and 2-hour glucose levels, to predict future diabetes. We built a prediction model using the baseline data and the diabetes status at biannual follow-up of 8 years. The mean area under curve (AUC) for all followups of the full model including all variables was 0.92 +/- 0.04 (mean +/- standard deviation), while that of the model excluding the mtDNA-CN was 0.90 +/- 0.03. The sensitivity of the f4ull model was much greater than that of the model not including mtDNA-CN: the mean sensitivities of the model with and without mtDNA-CN were 0.60 +/- 0.06 and 0.53 +/- 0.04, respectively. We found that the mtDNA-CN of peripheral leukocytes is a biomarker that augments the predictive power for future diabetes of A1C and OGTT. We believe that these results could provide invaluable information for developing strategies for the management of diabetes.
- URI
- https://www.nature.com/articles/srep43203https://repository.hanyang.ac.kr/handle/20.500.11754/113342
- ISSN
- 2045-2322
- DOI
- 10.1038/srep43203
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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