Relevance of mortalin to cancer cell stemness and cancer therapy
- Title
- Relevance of mortalin to cancer cell stemness and cancer therapy
- Author
- 윤채옥
- Keywords
- TO-MESENCHYMAL TRANSITION; STRESS CHAPERONE MORTALIN; BAX CONFORMATIONAL-CHANGE; TUMOR-SUPPRESSOR P53; HSP70 FAMILY-MEMBER; DRUG-RESISTANCE; CARCINOMA-CELLS; CYTOPLASMIC SEQUESTRATION; HUMAN CARCINOGENESIS; GLUCOSE DEPRIVATION
- Issue Date
- 2017-02
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v. 7, Article no. 42016
- Abstract
- Mortalin/mtHsp70 is a member of Hsp70 family of proteins. Enriched in a large variety of cancers, it has been shown to contribute to the process of carcinogenesis by multiple ways including inactivation of tumor suppressor p53 protein, deregulation of apoptosis and activation of EMT signaling. In this study, we report that upregulation of mortalin contributes to cancer cell stemness. Several cancer cell stemness markers, such as ABCG2, OCT-4, CD133, ALDH1, CD9, MRP1 and connexin were upregulated in mortalin-overexpressing cells that showed higher ability to form spheroids. These cells also showed higher migration, and were less responsive to a variety of cancer chemotherapeutic drugs. Of note, knockdown of mortalin by specific shRNA sensitized these cells to all the drugs used in this study. We report that low doses of anti-mortalin molecules, MKT-077 and CAPE, also caused similar sensitization of cancer cells to chemotherapeutic drugs and hence are potential candidates for effective cancer chemotherapy.
- URI
- https://www.nature.com/articles/srep42016https://repository.hanyang.ac.kr/handle/20.500.11754/112819
- ISSN
- 2045-2322
- DOI
- 10.1038/srep42016
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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