Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김성욱 | - |
dc.date.accessioned | 2019-11-20T06:18:56Z | - |
dc.date.available | 2019-11-20T06:18:56Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | BMC MEDICAL RESEARCH METHODOLOGY, v. 19, Article no. 49 | en_US |
dc.identifier.issn | 1471-2288 | - |
dc.identifier.uri | https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-019-0678-z | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/112556 | - |
dc.description.abstract | Background : In clinical trials and survival analysis, participants may be excluded from the study due to withdrawal, which is often referred to as lost-to-follow-up (LTF). It is natural to argue that a disease would be censored due to death; however, when an LTF is present it is not guaranteed that the disease has been censored. This makes it important to consider both cases; the disease is censored or not censored. We also note that the illness process can be censored by LTF. We will consider a multi-state model in which LTF is not regarded as censoring but as a non-fatal event. Methods : We propose a multi-state model for analyzing semi-competing risks data with interval-censored or missing intermediate events. More precisely, we employ the additive and multiplicative hazards model with log-normal frailty and construct the conditional likelihood to estimate the transition intensities among states in the multi-state model. Marginalization of the full likelihood is accomplished using adaptive importance sampling, and the optimal solution of the regression parameters is achieved through the iterative quasi-Newton algorithm. Results : Simulation is performed to investigate the finite-sample performance of the proposed estimation method in terms of the relative bias and coverage probability of the regression parameters. The proposed estimators turned out to be robust to misspecifications of the frailty distribution. PAQUID data have been analyzed and yielded somewhat prominent results. Conclusions : We propose a multi-state model for semi-competing risks data for which there exists information on fatal events, but information on non-fatal events may not be available due to lost to follow-up. Simulation results show that the coverage probabilities of the regression parameters are close to a nominal level of 0.95 in most cases. Regarding the analysis of real data, the risk of transition from a healthy state to dementia is higher for women; however, the risk of death after being diagnosed with dementia is higher for men. | en_US |
dc.description.sponsorship | This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03028535). The funding body had a role in the design of the study, analysis, and interpretation of 'paq1000' dataset, and in writing the manuscript as well. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BMC | en_US |
dc.subject | Additive and multiplicative hazards model | en_US |
dc.subject | Interval censoring | en_US |
dc.subject | log-normal frailty | en_US |
dc.subject | Missing intermediate event | en_US |
dc.subject | Multi-state model | en_US |
dc.subject | Semi-competing risks data | en_US |
dc.title | Additive-multiplicative hazards regression models for interval-censored semi-competing risks data with missing intermediate events | en_US |
dc.type | Article | en_US |
dc.relation.no | 49 | - |
dc.relation.volume | 19 | - |
dc.identifier.doi | 10.1186/s12874-019-0678-z | - |
dc.relation.page | 1-14 | - |
dc.relation.journal | BMC MEDICAL RESEARCH METHODOLOGY | - |
dc.contributor.googleauthor | Kim, Jinheum | - |
dc.contributor.googleauthor | Kim, Jayoun | - |
dc.contributor.googleauthor | Kim, Seong W. | - |
dc.relation.code | 2019039661 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF APPLIED MATHEMATICS | - |
dc.identifier.pid | seong | - |
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