Stereoselective Synthesis of (+)-SCH 351448: A Unique Ligand System for Sodium, Calcium, and Other Cations
- Title
- Stereoselective Synthesis of (+)-SCH 351448: A Unique Ligand System for Sodium, Calcium, and Other Cations
- Author
- 나명수
- Issue Date
- 2005-08
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF ORGANIC CHEMISTRY, v. 70, No. 16, Page. 6321-6329
- Abstract
- (+)-SCH 351448 (Na+ salt A) was synthesized employing ring-closing olefin metathesis reaction of an open diene diester intermediate for construction of the 28-membered macrodiolide structure. The open diene diester was prepared from the monomeric hydroxy carboxylic acid and two different olefin fragments. The monomeric hydroxy acid was synthesized via Julia-Julia coupling reaction of intermediates derived from the same olefinic fragments. Oxane units in these fragments were prepared by radical cyclization reactions of beta-alkoxyacrylates. Analogous SCH 351448 salts incorporating other mono- and divalent cations may be prepared. Under acidic conditions, SCH 351448 (Na+ salt A) was the most stable complex, but SCH 351448 (Ca2+ salt) and (Na+ salt B) appear to be physiologically important species.
- URI
- https://pubs.acs.org/doi/abs/10.1021/jo0507993https://repository.hanyang.ac.kr/handle/20.500.11754/111383
- ISSN
- 0022-3263; 1520-6904
- DOI
- 10.1021/jo0507993
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML