Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유혜현 | - |
dc.date.accessioned | 2019-06-12T08:07:40Z | - |
dc.date.available | 2019-06-12T08:07:40Z | - |
dc.date.issued | 2007-05 | - |
dc.identifier.citation | PLANTA MEDICA, v. 73, No. 5, Page. 444-450 | en_US |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.issn | 1439-0221 | - |
dc.identifier.uri | https://www.thieme-connect.com/products/ejournals/html/10.1055/s-2007-967178 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/106508 | - |
dc.description.abstract | Schisandra fruits (Schisandraceae) are often used in traditional medicine and can be taken concomitantly with conventional medicine. In this study, the effects of dibenzocyclooctadiene lignans from Schizandra chinensis on P-gp-mediated efflux were examined to investigate a possible interaction with P-gp substrates. The cellular accumulation of rhodamine-123 in Caco-2 cells was measured with 12 Schisandra lignans. Most compounds resulted in slight or moderate increases of rhodamin-1 23 cellular uptake, indicating their P-gp inhibitory activity. Among them, cleoxyschizandrin exhibited the most potent effect on the accumulation of rhodamine-123. Subsequently, bidirectional transports of digoxin and rhodamine-123 in Caco-2 cells were determined with cleoxyschizandrin, the most active compound for the rhodamine-123 assay. In the bidirectional transport study, apical-to-basal (A-to-B) transports of digoxin and rhodamine- 123 were increased, whereas basal-to-apical (B-to-A) transports were decreased by deoxyschizandrin in concentration- and time-dependent manners. At 50 mu M of deoxyschizandrin, the transport ratios (B-A/A-B) for digoxin and rhodamine-123 were 2.2 and 2.1 compared with the control ratios of 15.2 and 12.2, respectively. These results demonstrated that deoxyschizandrin effectively inhibited the P-gp-mediated efflux in Caco-2 cells, suggesting they could potentially increase the absorption of drugs that can act as a P-gp substrate. | en_US |
dc.description.sponsorship | This work was supported in part by Seoul Research and Business Development Program (10 524). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | GEORG THIEME VERLAG KG | en_US |
dc.subject | Schisandra chinensis | en_US |
dc.subject | Schisandraceae | en_US |
dc.subject | P-glycoprotein | en_US |
dc.subject | dibenzo-cyclooctadiene lignans | en_US |
dc.subject | deoxyschizandrin | en_US |
dc.subject | Caco-2 cells | en_US |
dc.title | Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells | en_US |
dc.type | Article | en_US |
dc.relation.volume | 73 | - |
dc.identifier.doi | 10.1055/s-2007-967178 | - |
dc.relation.page | 444-450 | - |
dc.relation.journal | PLANTA MEDICA | - |
dc.contributor.googleauthor | Yoo, Hye Hyun | - |
dc.contributor.googleauthor | Lee, Mijin | - |
dc.contributor.googleauthor | Lee, Min Woo | - |
dc.contributor.googleauthor | Lim, Sun Young | - |
dc.contributor.googleauthor | Shin, Jongheon | - |
dc.contributor.googleauthor | Kim, Dong-Hyun | - |
dc.relation.code | 2007207685 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | yoohh | - |
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