Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안성훈 | - |
dc.date.accessioned | 2019-06-10T01:32:55Z | - |
dc.date.available | 2019-06-10T01:32:55Z | - |
dc.date.issued | 2007-03 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v. 354, No. 3, Page. 769-775 | en_US |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0006291X07000885 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/106326 | - |
dc.description.abstract | Down-regulation of gelsolin expression is associated with cellular transformation and induction of gelsolin exerts antitumorigenic effects. In this study, we show that protein kinase C (PKC) signaling pathway is required for the induction of gelsolin by the histone deacetylase inhibitor apicidin in HeLa cells. Apicidin induces gelsolin mRNA independently of the de novo protein synthesis. Inhibitor study has revealed that the PKC signaling pathway is involved in the gelsolin expression. Furthermore, inhibition of PKC epsilon by either siRNA or dominant-negative mutant completely abrogates the expression of gelsolin by apicidin, indicating that PKC epsilon is the major isoform for this process. In parallel, apicidin induction of gelsolin is antagonized by the inhibition of Sp1 using dominant-negative Sp1 or specific Sp1 inhibitor mithramycin, and inhibition of PKC leads to suppression of Sp1 promoter activity. Our results provide mechanistic insights into molecular mechanisms of gelsolin induction by apicidin. (c) 2007 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by Grant No. 2003-041-E00317 from the Korea Research Foundation. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | en_US |
dc.subject | protein kinase C | en_US |
dc.subject | PKC epsilon | en_US |
dc.subject | histone deacetylase | en_US |
dc.subject | apicidin | en_US |
dc.subject | gelsolin | en_US |
dc.subject | Sp1 | en_US |
dc.title | PKCε is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.bbrc.2007.01.046 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.contributor.googleauthor | Eun, Dae-Wook | - |
dc.contributor.googleauthor | Ahn, Seong Hoon | - |
dc.contributor.googleauthor | You, Jeong Soo | - |
dc.contributor.googleauthor | Park, Jong Woo | - |
dc.contributor.googleauthor | Lee, Eun Kyung | - |
dc.contributor.googleauthor | Lee, Hyun Nah | - |
dc.contributor.googleauthor | Kang, Gil Myoung | - |
dc.contributor.googleauthor | Lee, Jae Cheol | - |
dc.contributor.googleauthor | Choi, Wahn Soo | - |
dc.contributor.googleauthor | Seo, Dong-Wan | - |
dc.contributor.googleauthor | Han, Jeung-Whan | - |
dc.relation.code | 2007201235 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF MOLECULAR AND LIFE SCIENCE | - |
dc.identifier.pid | hoon320 | - |
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