Estimating Negative Effect of Abdominal Obesity on Mildly Decreased Kidney Function Using a Novel Index of Body-Fat Distribution
- Title
- Estimating Negative Effect of Abdominal Obesity on Mildly Decreased Kidney Function Using a Novel Index of Body-Fat Distribution
- Author
- 이창화
- Keywords
- Abdominal Obesity; Densitometry; Trunk/Body Fat Mass Ratio; Glomerular Filtration Rate
- Issue Date
- 2017-01
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v. 32, no. 4, page. 613-620
- Abstract
- Abdominal obesity is a major risk factor of chronic kidney disease (CKD). Conventional obesity-related indicators, included body mass index (BMI), waist circumference (WC), and conicity index (C-index), have some limitations. We examined the usefulness of trunk/body fat mass ratio (T/Br) to predict negative effect of abnormal fat distribution on excretory kidney function. We analyzed anthropometric, biochemical and densitometric data from a nation-wide, population-based, case-control study (the Korean National Health and Nutrition Examination Survey [KNHANES] IV and V). A total of 11,319 participants were divided into 2 groups according to estimated glomerular filtration rate (eGFR, mL.min(-1).1.73 m(-2)) as follows: Group I (n= 7,980), eGFR >= 90 and <= 120; and group II (n= 3,339), eGFR >= 60 and < 90. Linear regression analysis revealed that T/Br was closely related to eGFR (beta = -0.3173, P < 0.001), and the correlation remained significant after adjustment for age, gender, BMI, WC, C-index, systolic blood pressure (BP), hemoglobin, and smoking amount (beta = -0.0987, P < 0.001). Logistic regression analysis showed that T/Br (odds ratio [OR] = 1.046; 95% confidence interval [CI] = 1.039-1.054) was significantly associated with early decline of kidney function, and adjustment for age, gender, BMI, C-index, systolic BP, hemoglobin, serum glucose level, high-density lipoprotein (HDL)cholesterol, and smoking amount did not reduce the association (OR = 1.020; 95% CI = 1.007-1.033). T/Br is useful in estimating the negative impact of abdominal obesity on the kidney function.
- URI
- https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2017.32.4.613https://repository.hanyang.ac.kr/handle/20.500.11754/105807
- ISSN
- 1011-8934; 1598-6357
- DOI
- 10.3346/jkms.2017.32.4.613
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
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