Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-05-23T00:31:05Z | - |
dc.date.available | 2019-05-23T00:31:05Z | - |
dc.date.issued | 2018-09 | - |
dc.identifier.citation | PHARMAZIE, v. 73, No. 9, Page. 498-502 | en_US |
dc.identifier.issn | 0031-7144 | - |
dc.identifier.uri | https://www.ingentaconnect.com/contentone/govi/pharmaz/2018/00000073/00000009/art00003 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/105712 | - |
dc.description.abstract | To develop a novel celecoxib (CXB)-loaded drug delivery system, numerous nanosuspensions were prepared with various polymers and surfactants using a wet media milling process, and their particle sizes were subsequently determined. A 24 full factorial design was used to identify the most appropriate preparation conditions. Pharmacokinetics of the selected nanosuspension were performed in rats and compared with those of a drug powder and a commercial CXB-loaded product. Among the carriers investigated, copovidone and sodium lauryl sulphate gave the smallest particle size of the drug in the nanosuspension. In particular, the nanosuspension prepared with 5% CXB, 4% copovidone, and 0.1% sodium lauryl sulphate, under the appropriate conditions, showed a particle size of approximately 190 nm, which was physically stable for at least 8 weeks. This nano-suspension provided a significantly higher plasma concentration and AUC in rats as compared with the drug powder and the commercial product. Thus, this novel CXB-loaded nanosuspension is a promising candidate with excellent stability and enhanced oral bioavailability. © 2018 Govi-Verlag Pharmazeutischer Verlag GmbH. All rights reserved. | en_US |
dc.description.sponsorship | Acknowledgements: This work was supported by the National Research Foundation (NRF) of South Korea grants funded by the South Korean government (MEST) (No. 2018R1A2B2004668) and a grant (16173MFDS542) from the Ministry of Food and Drug Safety in 2016. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH | en_US |
dc.title | Development of a novel celecoxib-loaded nanosuspension using a wet media milling process | en_US |
dc.type | Article | en_US |
dc.relation.volume | 73 | - |
dc.identifier.doi | 10.1691/ph.2018.8035 | - |
dc.relation.page | 498-502 | - |
dc.relation.journal | PHARMAZIE | - |
dc.contributor.googleauthor | Jeong, Sung Chan | - |
dc.contributor.googleauthor | Kim, Dong Shik | - |
dc.contributor.googleauthor | Jin, Sung Giu | - |
dc.contributor.googleauthor | Youn, Yu Seok | - |
dc.contributor.googleauthor | Oh, Kyung Taek | - |
dc.contributor.googleauthor | Li, Dong Xun | - |
dc.contributor.googleauthor | Yong, Chul Soon | - |
dc.contributor.googleauthor | Kim, Jong Oh | - |
dc.contributor.googleauthor | Kim, Kyeong Soo | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.relation.code | 2018002917 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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