Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-05-22T01:19:31Z | - |
dc.date.available | 2019-05-22T01:19:31Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.citation | NANOSCALE, v. 10, No. 4, Page. 1742-1749 | en_US |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.uri | https://pubs.rsc.org/en/Content/ArticleLanding/2018/NR/C7NR07603G#!divAbstract | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/105359 | - |
dc.description.abstract | A vibrating nozzle approach was used to produce uniform (similar to 2 mu m) hybrid droplets containing gold-graphene oxide (Au-GO), doxorubicin (DOX), and zwitterionic chitosan (ZC) for assembly of Au-GO@ZC-DOX stealth nanovesicles (NVs) via a single-pass diffusion drying process without any hydrothermal reactions, separations, or purifications. NVs were prepared with a lateral dimension of similar to 53.0 nm, a pH-triggered high DOX release profile, and strong photothermal effects. Macrophage opsonization was prevented, resulting in anti-cancer and anti-migration effects, with high intracellular uptake in PANC-1 and MIA PaCa-2 cells. PANC-1 tumor uptake was greater for NVs having the ZC configuration than that for NVs without the ZC configuration, resulting in better anti-tumor effects with minimal toxicities. The vibrating nozzle approach offers significant potential to assemble multi-componential NVs for more efficient anti-tumor treatment and easy user-defined manufacturing of multifunctional nanomedicines. | en_US |
dc.description.sponsorship | This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2015R1A2A2A01004118, 2015R1A2A2A04-004806, and 2015R1A2A2A04005809). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ROYAL SOC CHEMISTRY | en_US |
dc.subject | LIQUID-CRYSTALLINE NANOPARTICLES | en_US |
dc.subject | DRUG-DELIVERY-SYSTEMS | en_US |
dc.subject | IN-VIVO | en_US |
dc.subject | BREAST-CANCER | en_US |
dc.subject | CELLULAR UPTAKE | en_US |
dc.subject | THERAPY | en_US |
dc.subject | PH | en_US |
dc.subject | DOXORUBICIN | en_US |
dc.subject | RELEASE | en_US |
dc.subject | NANOMEDICINE | en_US |
dc.title | Vibrating droplet generation to assemble zwitterion-coated gold-graphene oxide stealth nanovesicles for effective pancreatic cancer chemo-phototherapy | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.1039/c7nr07603g | - |
dc.relation.page | 1742-1749 | - |
dc.relation.journal | NANOSCALE | - |
dc.contributor.googleauthor | Thapa, Raj Kumar | - |
dc.contributor.googleauthor | Ku, Sae Kwang | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.contributor.googleauthor | Yong, Chul Soon | - |
dc.contributor.googleauthor | Byeon, Jeong Hoon | - |
dc.contributor.googleauthor | Kim, Jong Oh | - |
dc.relation.code | 2018000106 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.